Chemistry:5-Fluoro-DMT
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Short description: Chemical compound
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| Formula | C12H15FN2 |
| Molar mass | 206.264 g·mol−1 |
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5-Fluoro-N,N-dimethyltryptamine (5-fluoro-DMT, 5F-DMT) is a tryptamine derivative related to compounds such as 5-bromo-DMT and 5-MeO-DMT.[1] Fluorination of psychedelic tryptamines either reduces or has little effect on 5-HT2A/C receptor affinity or intrinsic activity, although 6-fluoro-DET is inactive as a psychedelic despite acting as a 5-HT2A agonist (cf. lisuride), while 4-fluoro-5-methoxy-DMT is a much stronger agonist at 5-HT1A than 5-HT2A.[2][3]
See also
- 5-Fluoro-AMT
- 5-Fluoro-DET
- 5-Fluoro-MET
- 6-fluoro-AMT
- 6-Fluoro-DMT
- 4-fluoro-5-methoxy-DMT
- 6-Fluoro-DET(6-Fluoro-DET)
- O-4310
- It's worth noting that GR-159897 is based on the same structure.
References
- ↑ "Improved Fischer indole reaction for the preparation of N, N-dimethyltryptamines: Synthesis of L-695,894, a potent 5-HT1D receptor agonist.". The Journal of Organic Chemistry 59 (13): 3738–3741. July 1994. doi:10.1021/jo00092a046.
- ↑ "Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines". Journal of Medicinal Chemistry 43 (24): 4701–10. November 2000. doi:10.1021/jm000339w. PMID 11101361.
- ↑ "5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens". Pharmacology, Biochemistry, and Behavior 72 (1–2): 29–37. May 2002. doi:10.1016/S0091-3057(01)00720-1. PMID 11900766.
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