Chemistry:4-HO-DET
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| Formula | C14H20N2O |
| Molar mass | 232.327 g·mol−1 |
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| Melting point | 104 to 106 °C (219 to 223 °F) |
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4-HO-DET, also known as 4-hydroxy-diethyl-tryptamine, CZ-74, is a hallucinogenic drug and psychedelic compound of moderate duration. 4-HO-DET is a substituted tryptamine, structurally related to psilocin, ethocybin, and 4-HO-DIPT.[1]
Analogs
4-HO-DET is the N,N-diethyl analog of psilocin. The acetic acid ester of 4-HO-DET is known as 4-AcO-DET and the phosphoric acid ester of 4-HO-DET is known as 4-phosphoryloxy-DET, CEY-19, or ethocybin. These compounds may likely be prodrugs of 4-HO-DET as has been shown with the acetate and phospate esters of other methylated tryptamines such as psilocin.[2]
History
4-HO-DET received the lab code CZ-74 in the late 1950s by the inventors of the substance, Albert Hofmann and Franz Troxler. The substance was used together with its phosphoryloxy-analog ethocybin in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer.[citation needed] It was later explored by Alexander Shulgin in his 1997 book TiHKAL.[3]
Dosage
TiHKAL reports moderate effects at 10–25 mg ingested orally.[4]
Effects
4-HO-DET produces psychedelic effects similar to LSD and psilocybin.[4]
Legality
United States
4-HO-DET is unscheduled in the United States, but purchase, sale, or possession for human consumption could be prosecuted under the Federal Analogue Act.[5]
Sweden
Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-HO-DET as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Nov 1, 2005, in their regulation SFS 2005:733 listed as 4-hydroxi-N,N-diethyltryptamin (4-HO-DET), making it illegal to sell or possess.[6]
See also
References
- ↑ "Tryptamines". Novel Psychoactive Substances: Classification, Pharmacology and Toxicology (Second ed.). London, United Kingdom: Academic Press. 2021. p. 499. ISBN 978-0-12-819030-2. https://books.google.com/books?id=8WIFEAAAQBAJ&dq=4-HO-DET&pg=PA499.
- ↑ "Improvements to the Synthesis of Psilocybin and a Facile Method for Preparing the O-Acetyl Prodrug of Psilocin". Synthesis 1999 (6): 935–938. February 11, 1999. doi:10.1055/s-1999-3490. http://www.thieme-connect.de/DOI/DOI?10.1055/s-1999-3490.
- ↑ Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252. http://www.erowid.org/library/books_online/tihkal/tihkal.shtml.
- ↑ 4.0 4.1 "#16 4-HO-DET". Transform Press. September 1997. http://isomerdesign.com/PiHKAL/read.php?id=16&domain=tk.
- ↑ "21 U.S. Code § 841 - Prohibited acts A". https://www.law.cornell.edu/uscode/text/21/841.
- ↑ "Förordning om ändring i förordningen (1999:58) om förbud mot vissa hälsofarliga varor;" (in sv). Svensk författningssamling (Swedish Code of Statutes). 6 October 2005. http://www.notisum.se/rnp/sls/sfs/20050733.pdf.
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