Chemistry:Acetryptine

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Short description: Drug
Acetryptine
Acetryptine.svg
Clinical data
Other namesW-2965-A; 5-Acetyltryptamine; 5-Acetyl-3-(2-aminoethyl)indole;
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC12H14N2O
Molar mass202.257 g·mol−1
3D model (JSmol)

Acetryptine (INN) (developmental code name W-2965-A), also known as 5-acetyltryptamine (5-AT),[1] is a drug described as an antihypertensive agent which was never marketed.[2] Structurally, acetryptine is a substituted tryptamine, and is closely related to other substituted tryptamines like serotonin (5-hydroxytryptamine).[2] It was developed in the early 1960s.[2][1] The binding of acetryptine to serotonin receptors does not seem to have been well-investigated, although it was assessed at the 5-HT1A and 5-HT1D receptors and found to bind to them with high affinity.[3] The drug may also act as a monoamine oxidase inhibitor (MAOI); specifically, as an inhibitor of MAO-A.[4][5]

See also


References

  1. ↑ 1.0 1.1 "Tissue distribution and metabolism of 5-acetyltryptamine in the mouse". Biochem. Pharmacol. 12 (6): 585–8. 1963. doi:10.1016/0006-2952(63)90136-9. PMID 13953098. 
  2. ↑ 2.0 2.1 2.2 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 6–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA6. 
  3. ↑ "Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors". J. Med. Chem. 39 (1): 314–22. 1996. doi:10.1021/jm950498t. PMID 8568822. 
  4. ↑ "Modeling of substrate-binding region of the active site of monoamine oxidase A". Biochemistry Mosc. 65 (8): 910–6. 2000. PMID 11002183. 
  5. ↑ "Monoamine oxidases: to inhibit or not to inhibit". Mini Rev Med Chem 3 (2): 129–36. 2003. doi:10.2174/1389557033405287. PMID 12570845. 




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