Chemistry:5-MeO-DPT

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5-MeO-DPT, also known as 5-methoxy-N,N-dipropyltryptamine, as well as O-methyl-N,N-dipropylserotonin (O-Me-DiPS), is a psychedelic and entheogenic designer drug of the tryptamine family related to dipropyltryptamine (DPT) and 5-MeO-DMT.[1][2][3][4][5]

Use and effects

5-MeO-DPT is orally active, with 6 to 10 mg representing a fully effective dose.[1] Effects begin within 1 hour, and usually last 2 to 4 hours.[1]

Little is known about the subjective effects of 5-MeO-DPT, but the nature of the compound is probably comparable to 5-MeO-DiPT, 5-MeO-DMT, or DPT, which are also psychedelic tryptamines/indoles. However, the duration of the above-mentioned drugs vary considerably.

Interactions

Pharmacology

Pharmacodynamics

5-MeO-DPT shows affinity for the serotonin 5-HT1A receptor (Ki = 4.0 nM), the serotonin 5-HT1B receptor (Ki = 1,800 nM), and the serotonin 5-HT2 receptor (Ki = 7.1–655 nM).[6] It fully substitutes for DOM in rodent drug discrimination tests and partially substitutes for 8-OH-DPAT in these tests followed by behavioral disruption at higher doses.[6] 5-MeO-DPT also substitutes for 5-MeO-DMT in rodent drug discrimination tests.[7]

Chemistry

The full chemical name is N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-propylpropan-1-amine. It is classified as a tryptamine derivative.

Society and culture

In the United States, 5-MeO-DPT is considered a Schedule I controlled substance as a positional isomer of 5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT)[8]

See also

References

  1. ↑ 1.0 1.1 1.2 Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252. http://www.erowid.org/library/books_online/tihkal/tihkal.shtml. 
  2. ↑ "Hallucinogenic agents as discriminative stimuli: a correlation with serotonin receptor affinities". Psychopharmacology 68 (2): 155–8. 1980. doi:10.1007/BF00432133. PMID 6776558. 
  3. ↑ "Identification and quantitative determination of 5-methoxy-N, N-di-n-propyltryptamine in urine by isotope dilution gas chromatography-mass spectrometry.". Forensic Toxicology 25 (1): 1–7. June 2007. doi:10.1007/s11419-006-0018-y. 
  4. ↑ "Simultaneous determination of tryptamine analogues in designer drugs using gas chromatography–mass spectrometry and liquid chromatography–tandem mass spectrometry.". Forensic Toxicology 32 (1): 154–61. January 2014. doi:10.1007/s11419-013-0208-3. 
  5. ↑ "5-Meth-oxy-N,N-di-n-propyl-tryptamine (5-MeO-DPT): freebase and fumarate". Acta Crystallographica Section E 77 (Pt 5): 522–526. May 2021. doi:10.1107/S2056989021003753. PMID 34026257. Bibcode: 2021AcCrE..77..522P. 
  6. ↑ 6.0 6.1 "N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin". J Med Chem 31 (4): 867–870. April 1988. doi:10.1021/jm00399a031. PMID 2965244. 
  7. ↑ "Hallucinogenic agents as discriminative stimuli: a correlation with serotonin receptor affinities". Psychopharmacology (Berl) 68 (2): 155–158. 1980. doi:10.1007/BF00432133. PMID 6776558. 
  8. ↑ "Lists of: Scheduling Actions Controlled Substances Regulated Chemicals". U.S. Department of Justice. February 2023. https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf. 

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