Chemistry:5-MeO-MALT

From HandWiki

5-MeO-MALT, also known as 5-methoxy-N-methyl-N-allyltryptamine, is a psychedelic drug of the tryptamine family related to 5-MeO-DALT.[1][2][3]

5-MeO-MALT was first described in the literature in 2004.[1] It was encountered as a novel designer drug in 2014.[4][5] The drug's pharmacology was studied and described in greater detail in 2024.[6]

Use and effects

5-MeO-MALT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).[7]

Interactions

Pharmacology

Pharmacodynamics

The pharmacology of 5-MeO-MALT has been studied.[6] It is a potent serotonin 5-HT2A receptor agonist and produces the head-twitch response in rodents.[6] The drug also shows high affinity for the serotonin 5-HT1A receptor.[6]

Chemistry

Analogues

Analogues of 5-MeO-MALT include methylallyltryptamine (MALT), 4-HO-MALT (maltocin), 4-AcO-MALT, 5-MeO-DMT, 5-MeO-DET, 5-MeO-DPT, 5-MeO-DiPT, 5-MeO-DALT, 5-MeO-MET, 5-MeO-MPT, 5-MeO-MiPT, 5-MeO-EiPT, and 5-MeO-iPALT (ASR-3001), among others.

Society and culture

Canada

5-MeO-MALT is not a controlled substance in Canada as of 2025.[8]

Hungary

5-MeO-MALT is illegal in Hungary.[9]

Sweden

Sweden's public health agency suggested classifying 5-MeO-MALT as a hazardous substance, on May 15, 2019.[10][11]

United States

5-MeO-MALT is not an explicitly controlled substance in the United States.[12] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

References

  1. ↑ 1.0 1.1 Jensen N (4 November 2004). Tryptamines as Ligands and Modulators of the Serotonin 5-HT2A Receptor and the Isolation of Aeruginascin from the Hallucinogenic Mushroom Inocybe aeruginascens (PDF) (Ph.D. thesis). Georg-August-Universität zu Göttingen. Retrieved 19 October 2015.
  2. ↑ "5-MeO-MALT". WEDINOS - Welsh Emerging Drugs & Identification of Novel Substance Project. Public Health Wales. http://www.wedinos.org/db/materials/view/00627. 
  3. ↑ "Psykotisk ungdom ruset på motedop raserte pasientrom" (in Norwegian). VG. 30 April 2015. http://www.vg.no/forbruker/narkotika/psykotisk-ungdom-ruset-paa-motedop-raserte-pasientrom/a/23443540/. 
  4. ↑ EMCDDA (European Monitoring Centre for Drugs and Drug Addiction) (2015) New psychoactive substances in Europe - an update from the EU Early Warning System. Publications Office of the European Union, Luxembourg. http://www.emcdda.europa.eu/publications/ 2015/new-psychoactive-substances. Accessed 15 Nov 2015
  5. ↑ "NPS: Medical Consequences Associated with Their Intake". Curr Top Behav Neurosci 32: 351–380. 2017. doi:10.1007/7854_2016_15. PMID 27272067. 
  6. ↑ 6.0 6.1 6.2 6.3 "Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties". Mol Psychiatry 29 (8): 2346–2358. August 2024. doi:10.1038/s41380-024-02506-8. PMID 38486047. 
  7. ↑ Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252. http://www.erowid.org/library/books_online/tihkal/tihkal.shtml. 
  8. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 
  9. ↑ "A Magyarországon megjelent, a Kábítószer és Kábítószer-függőség Európai Megfigyelő Központjának Korai Jelzőrendszerébe (EMCDDA EWS)" (in Hungarian). óta bejelentett ellenőrzött anyagok büntetőjogi vonatkozású besorolása. http://www.daath.hu/incoming/designer_jogi_lista_20150903_BSZKI_Daath_kieg.pdf. 
  10. ↑ "Folkhälsomyndigheten föreslår att 20 ämnen klassas som narkotika eller hälsofarlig vara" (in sv). Folkhälsomyndigheten. 15 May 2019. https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2019/maj/folkhalsomyndigheten-foreslar-att-20-amnen-klassas-som-narkotika-eller-halsofarlig-vara/. 
  11. ↑ "5-MeO-MALT (5-MeOMALT)" (in ru). https://aipsin.com/newsubstance/157/. 
  12. ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf 



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