Chemistry:4-HO-MALT

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4-HO-MALT, also known as 4-hydroxy-N-methyl-N-allyltryptamine or as maltocin, is a tryptamine derivative related to 4-HO-DALT (dalocin) which has been sold as a designer drug, first being detected in Slovenia in 2020.[1][2]

Use and effects

4-HO-MALT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).[3] However, it has subsequently emerged as a novel designer drug.[4] It is said to have a dose of 10 to 40 mg orally, with its effects including mild stimulation and visual changes.[4]

Interactions

Pharmacology

Pharmacodynamics

4-HO-MALT acts as an agonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors.[5] It also interacts with other serotonin receptors. The drug produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.[5]

Chemistry

Analogues

Analogues of 4-HO-MALT include methylallyltryptamine (MALT), 4-AcO-MALT, 5-MeO-MALT, 4-HO-DALT, 4-AcO-DALT, 4-HO-NALT, 4-HO-MiPT, 4-HO-McPT, and 4-HO-MPT, among others.

History

4-HO-MALT was encountered online as a novel designer drug in 2018 and 2019.[4][6] Subsequently, it was detected in Slovenia in 2020.[1][2][6]

Society and culture

Canada

4-HO-MALT is not a controlled substance in Canada as of 2025.[7]

See also

References

  1. ↑ 1.0 1.1 "Investigation of the Structure-Activity Relationships of Psilocybin Analogues". ACS Pharmacology & Translational Science 4 (2): 533–542. April 2021. doi:10.1021/acsptsci.0c00176. PMID 33860183. 
  2. ↑ 2.0 2.1 European Monitoring Centre for Drugs and Drug Addiction. (June 2022). New psychoactive substances: 25 years of early warning and response in Europe. An update from the EU Early Warning System. European Monitoring Centre for Drugs and Drug Addiction. doi:10.2810/882318. ISBN 978-92-9497-737-3. https://www.emcdda.europa.eu/system/files/publications/14637/20222218_PDF_TD0522113ENN_002.pdf. 
  3. ↑ Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252. http://www.erowid.org/library/books_online/tihkal/tihkal.shtml. 
  4. ↑ 4.0 4.1 4.2 "4-HO-MALT" (in ru). https://aipsin.com/newsubstance/238/. 
  5. ↑ 5.0 5.1 "Investigation of the Structure-Activity Relationships of Psilocybin Analogues". ACS Pharmacol Transl Sci 4 (2): 533–542. April 2021. doi:10.1021/acsptsci.0c00176. PMID 33860183. 
  6. ↑ 6.0 6.1 "4-HO-MALT" (in ru). https://aipsin.com/newsubstance/677/. 
  7. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 



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