Chemistry:ML-SI3
From HandWiki
Short description: Chemical compound
 | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| Chemical and physical data | |
| Formula | C23H31N3O3S |
| Molar mass | 429.58 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
ML-SI3 is a chemical compound which acts as an "antagonist" (i.e. channel blocker) of the TRPML family of calcium channels, with greatest activity at the TRPML1 channel, although it also blocks the related TRPML2 and TRPML3 channels with lower affinity. It is used for research into the role of TRPML1 and its various functions in lysosomes and elsewhere in the body.[1][2][3][4][5][6][7]
See also
References
- ↑ "Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx". Journal of Cell Science 129 (20): 3859–3867. October 2016. doi:10.1242/jcs.190322. PMID 27577094.
- ↑ "A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation". Nature Cell Biology 18 (4): 404–17. April 2016. doi:10.1038/ncb3324. PMID 26950892.
- ↑ "2+ Efflux Channel in the Tubulovesicle". Developmental Cell 41 (3): 262–273.e6. May 2017. doi:10.1016/j.devcel.2017.04.003. PMID 28486130.
- ↑ "TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway". Nature Communications 10 (1): 5630. December 2019. doi:10.1038/s41467-019-13572-w. PMID 31822666.
- ↑ "Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR". PLoS Biology 17 (5): e3000252. May 2019. doi:10.1371/journal.pbio.3000252. PMID 31112550.
- ↑ "Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress". Autophagy: 1–16. March 2020. doi:10.1080/15548627.2020.1739442. PMID 32138578.
- ↑ "Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3.". European Journal of Medicinal Chemistry: 112966. October 2020. doi:10.1016/j.ejmech.2020.112966.
 |  |
