Chemistry:Ononetin
From HandWiki
Short description: Chemical compound
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| Formula | C15H14O4 |
| Molar mass | 258.273 g·mol−1 |
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Ononetin is a natural product from the deoxybenzoin group, which is found in the Russian traditional medicine plant Ononis spinosa. It acts as an inhibitor of the transient receptor potential ion channel TRPM3 and has analgesic effects in animal studies,[1][2] as well as being used for research into the role of TRPM3 in the immune system dysfunction associated with chronic fatigue syndrome.[3][4]
References
- ↑ "Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3". British Journal of Pharmacology 168 (8): 1835–50. April 2013. doi:10.1111/bph.12076. PMID 23190005.
- ↑ "Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo". Molecular Pharmacology 84 (5): 736–50. November 2013. doi:10.1124/mol.113.086843. PMID 24006495.
- ↑ "Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients". Molecular Medicine 25 (1): 14. April 2019. doi:10.1186/s10020-019-0083-4. PMID 31014226.
- ↑ "Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients". Frontiers in Immunology 10: 2545. 2019. doi:10.3389/fimmu.2019.02545. PMID 31736966.
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