Chemistry:PF-04745637

From HandWiki
Short description: Chemical compound
PF-04745637
PF-04745637 structure.png
Identifiers
CAS Number
PubChem CID
ChEMBL
Chemical and physical data
FormulaC27H32ClF3N2O2
Molar mass509.01 g·mol−1
3D model (JSmol)

PF-04745637 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor, with an IC50 of 17nM, vs ~3μM at the related TRPV1 and TRPM channels. It has antiinflammatory effects and was developed as a potential treatment for conditions such as atopic dermatitis.[1]

References

  1. "The discovery of a potent series of carboxamide TRPA1 antagonists.". MedChemComm 7 (11): 2145–58. 2016. doi:10.1039/C6MD00387G.