Chemistry:RN-9893

RN-9893
Identifiers
	IUPAC name 2-nitro-N-[4-(4-propan-2-ylpiperazin-1-yl)sulfonylphenyl]-4-(trifluoromethyl)benzamide;
CAS Number	2109450-40-8;
PubChem CID	121513880;
Chemical and physical data
Formula	C21H23F3N4O5S
Molar mass	500.49 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)N1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=C(C=C(C=C3)C(F)(F)F)[N+](=O)[O-];
	InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29); Key:KORKKQLDGMHNKO-UHFFFAOYSA-N;

Short description: Chemical compound

RN-9893 is a drug which acts as a potent and selective blocker of the TRPV4 ion channel. It has been used to investigate the role of TRPV4 channels in the function of heart valves.^[1]^[2]

References

↑ "Identification of orally-bioavailable antagonists of the TRPV4 ion-channel". Bioorganic & Medicinal Chemistry Letters 25 (18): 4011–5. September 2015. doi:10.1016/j.bmcl.2015.06.098. PMID 26235950.
↑ "Expression and function of mechanosensitive ion channels in human valve interstitial cells". PLOS ONE 15 (10): e0240532. 2020. doi:10.1371/journal.pone.0240532. PMID 33057457. Bibcode: 2020PLoSO..1540532A.

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[1] "Identification of orally-bioavailable antagonists of the TRPV4 ion-channel". Bioorganic & Medicinal Chemistry Letters 25 (18): 4011–5. September 2015. doi:10.1016/j.bmcl.2015.06.098. PMID 26235950.

[2] "Expression and function of mechanosensitive ion channels in human valve interstitial cells". PLOS ONE 15 (10): e0240532. 2020. doi:10.1371/journal.pone.0240532. PMID 33057457. Bibcode: 2020PLoSO..1540532A.

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Identifiers

IUPAC name 2-nitro-N-[4-(4-propan-2-ylpiperazin-1-yl)sulfonylphenyl]-4-(trifluoromethyl)benzamide
CAS Number	2109450-40-8
PubChem CID	121513880
Chemical and physical data
Formula	C₂₁H₂₃F₃N₄O₅S
Molar mass	500.49 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(C)N1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=C(C=C(C=C3)C(F)(F)F)[N+](=O)[O-]
InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29) Key:KORKKQLDGMHNKO-UHFFFAOYSA-N

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