Chemistry:SET2

Short description: Chemical compound

SET2

Identifiers
IUPAC name N-(furan-2-ylmethyl)-3-({4-[methyl(propyl)amino]-6-(trifluoromethyl)pyrimidin-2-yl}sulfanyl)propanamide
ChemSpider	88296672
Chemical and physical data
Formula	C17H21F3N4O2S
Molar mass	402.44 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(CCSc1nc(cc(n1)N(C)CCC)C(F)(F)F)NCc2ccco2
InChI InChI=1S/C17H21F3N4O2S/c1-3-7-24(2)14-10-13(17(18,19)20)22-16(23-14)27-9-6-15(25)21-11-12-5-4-8-26-12/h4-5,8,10H,3,6-7,9,11H2,1-2H3,(H,21,25) Key:LZHSWRWIMQRTOP-UHFFFAOYSA-N

SET2 is a drug which acts as a selective antagonist for the TRPV2 receptor. It is moderately potent with an IC₅₀ of 460nM, but is highly selective for TRPV2 over the other subtypes of TRPV, and is the first such compound to be developed. A role has been suggested for TRPV2 in tumor metastasis, making this a target of interest in the treatment of cancer.

See also

• HC-067047
• ZINC17988990