Chemistry:TRPM4-IN-5
From HandWiki
Short description: Chemical compound
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| Formula | C15H11Cl2NO4 |
| Molar mass | 340.16 g·mol−1 |
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TRPM4-IN-5 is a drug which acts as a moderately potent but highly selective blocker of the TRPM4 ion channel, with an IC50 of 1.5μM.[1] It is protective against glutamate mediated neuronal excitotoxicity.[2]
References
- ↑ "Identification of potent and selective small molecule inhibitors of the cation channel TRPM4". British Journal of Pharmacology 175 (12): 2504–2519. June 2018. doi:10.1111/bph.14220. PMID 29579323.
- ↑ "The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration". Molecular Brain 11 (1): 41. July 2018. doi:10.1186/s13041-018-0385-4. PMID 29996905.
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