Chemistry:A-967079

A-967079
Identifiers
	IUPAC name (1E,3E)-1-(4-fluorophenyl)-2-methyl-1-penten-3-one oxime;
CAS Number	1170613-55-4;
PubChem CID	60150207;
ChemSpider	28294676;
UNII	S15N98QQ2K;
ChEMBL	ChEMBL3697710;
Chemical and physical data
Formula	C12H14FNO
Molar mass	207.248 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC/C(=N/O)/C(=C/C1=CC=C(C=C1)F)/C;
	InChI InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12-; Key:HKROEBDHHKMNBZ-BYKJOZEVSA-N;

Short description: Chemical compound

A-967079 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor. It has analgesic and antiinflammatory effects and is used in scientific research, but has not been developed for medical use.^[1]^[2]^[3]^[4]^[5]

References

↑ "Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation". Pain 152 (5): 1165–72. May 2011. doi:10.1016/j.pain.2011.01.049. PMID 21402443.
↑ "Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain". Anesthesiology 117 (1): 137–48. July 2012. doi:10.1097/ALN.0b013e31825adb0e. PMID 22588108.
↑ "Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist". The Journal of Biological Chemistry 289 (46): 31927–39. November 2014. doi:10.1074/jbc.M114.586891. PMID 25271161.
↑ "TRPA1: a transducer and amplifier of pain and inflammation". Basic & Clinical Pharmacology & Toxicology 114 (1): 50–5. January 2014. doi:10.1111/bcpt.12138. PMID 24102997.
↑ "TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation". Toxicology Letters 293: 140–148. September 2018. doi:10.1016/j.toxlet.2018.03.007. PMID 29535050.

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Original source: https://en.wikipedia.org/wiki/A-967079. Read more

[1] "Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation". Pain 152 (5): 1165–72. May 2011. doi:10.1016/j.pain.2011.01.049. PMID 21402443.

[2] "Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain". Anesthesiology 117 (1): 137–48. July 2012. doi:10.1097/ALN.0b013e31825adb0e. PMID 22588108.

[3] "Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist". The Journal of Biological Chemistry 289 (46): 31927–39. November 2014. doi:10.1074/jbc.M114.586891. PMID 25271161.

[4] "TRPA1: a transducer and amplifier of pain and inflammation". Basic & Clinical Pharmacology & Toxicology 114 (1): 50–5. January 2014. doi:10.1111/bcpt.12138. PMID 24102997.

[5] "TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation". Toxicology Letters 293: 140–148. September 2018. doi:10.1016/j.toxlet.2018.03.007. PMID 29535050.

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IUPAC name (1E,3E)-1-(4-fluorophenyl)-2-methyl-1-penten-3-one oxime
CAS Number	1170613-55-4
PubChem CID	60150207
ChemSpider	28294676
UNII	S15N98QQ2K
ChEMBL	ChEMBL3697710
Chemical and physical data
Formula	C₁₂H₁₄FNO
Molar mass	207.248 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC/C(=N/O)/C(=C/C1=CC=C(C=C1)F)/C
InChI InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12- Key:HKROEBDHHKMNBZ-BYKJOZEVSA-N

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