Chemistry:A-967079
From HandWiki
Short description: Chemical compound
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| Formula | C12H14FNO |
| Molar mass | 207.248 g·mol−1 |
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A-967079 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor. It has analgesic and antiinflammatory effects and is used in scientific research, but has not been developed for medical use.[1][2][3][4][5]
References
- ↑ "Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation". Pain 152 (5): 1165–72. May 2011. doi:10.1016/j.pain.2011.01.049. PMID 21402443.
- ↑ "Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain". Anesthesiology 117 (1): 137–48. July 2012. doi:10.1097/ALN.0b013e31825adb0e. PMID 22588108.
- ↑ "Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist". The Journal of Biological Chemistry 289 (46): 31927–39. November 2014. doi:10.1074/jbc.M114.586891. PMID 25271161.
- ↑ "TRPA1: a transducer and amplifier of pain and inflammation". Basic & Clinical Pharmacology & Toxicology 114 (1): 50–5. January 2014. doi:10.1111/bcpt.12138. PMID 24102997.
- ↑ "TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation". Toxicology Letters 293: 140–148. September 2018. doi:10.1016/j.toxlet.2018.03.007. PMID 29535050.
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