Chemistry:ML-SA1
From HandWiki
Short description: Chemical compound
 | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C22H22N2O3 |
| Molar mass | 362.429 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
ML-SA1 is a chemical compound which acts as an "agonist" (i.e. channel opener) of the TRPML family of calcium channels. It has mainly been studied for its role in activating TRPML1 channels, although it also shows activity at the less studied TRPML2 and TRPML3 subtypes. TRPML1 is important for the function of lysosomes, and ML-SA1 has been used to study several disorders resulting from impaired lysosome function, including mucolipidosis type IV and Niemann-Pick's disease type C,[1][2][3][4] as well as other conditions such as stroke and Alzheimer's disease.[5][6]
References
- ↑ "Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1". Cell Calcium 56 (6): 446–56. December 2014. doi:10.1016/j.ceca.2014.09.004. PMID 25266962.
- ↑ "2+ Signaling is Essential for Osteoclastogenesis and Bone Remodeling". Journal of Bone and Mineral Research 32 (2): 385–396. February 2017. doi:10.1002/jbmr.2986. PMID 27589205.
- ↑ "Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation". FASEB Journal 32 (2): 782–794. February 2018. doi:10.1096/fj.201700220RR. PMID 29030399.
- ↑ "2-mediated human TRPML1 regulation". Nature Communications 9 (1): 4192. October 2018. doi:10.1038/s41467-018-06493-7. PMID 30305615.
- ↑ "Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia". Oxidative Medicine and Cellular Longevity 2018: 4612727. doi:10.1155/2018/4612727. PMID 30662583.
- ↑ "Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis". Journal of Alzheimer's Disease 67 (1): 393–410. doi:10.3233/JAD-180941. PMID 30594929.
 |  |
