Chemistry:4-AcO-MET
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| Other names | 4-Acetoxy-MET; Metacetin; 4-Acetoxy-N-methyl-N-ethyltryptamine |
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| Formula | C15H20N2O2 |
| Molar mass | 260.337 g·mol−1 |
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4-acetoxy-MET (4-acetoxy-N-methyl-N-ethyltryptamine), also known as 4-AcO-MET or metacetin, is a hallucinogenic tryptamine. It is the acetate ester of 4-HO-MET, and a homologue of 4-AcO-DMT. It is a novel compound with very little history of human use.[1] It is sometimes sold as a research chemical by online retailers.
Due to its similarity to the psilocin prodrug 4-AcO-DMT, which is deacetylated to form psilocin in vivo,[2][3] it is expected that 4-AcO-MET is also quickly hydrolyzed into 4-HO-MET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.
Legality
In the United States, 4-Acetoxy-MET is not scheduled. It may be considered an analogue of psilocin, a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical purposes could be considered a crime under the Federal Analogue Act.[4]
In Switzerland, 4-Acetoxy-MET is a controlled substance under Verzeichnis E.[5]
In the United Kingdom, 4-Acetoxy-MET is a Class A drug in the UK because it is an ester of the drug 4-HO-MET, which is a Class A drug under the tryptamine catch-all clause.[6]
References
- ↑ "New psychoactive substances reported to the EMCDDA and Europol for the first time in 2009 under the terms of Council Decision 2005/387/JHA". https://www.emcdda.europa.eu/attachements.cfm/att_101538_EN_Annex%202.pdf.
- ↑ "Improvements to the Synthesis of Psilocybin and a Facile Method for Preparing the O-Acetyl Prodrug of Psilocin". Synthesis 1999 (6): 935–938. February 1999. doi:10.1055/s-1999-3490. http://www.thieme-connect.de/DOI/DOI?10.1055/s-1999-3490.
- ↑ "Psilacetin derivatives: fumarate salts of the meth-yl-ethyl, meth-yl-allyl and diallyl variants of the psilocin prodrug". Acta Crystallographica. Section e, Crystallographic Communications 77 (Pt 2): 101–106. February 2021. doi:10.1107/S2056989021000116. PMID 33614134. Bibcode: 2021AcCrE..77..101P.
- ↑ "21 U.S. Code § 841 - Prohibited acts A". https://www.law.cornell.edu/uscode/text/21/841.
- ↑ "Fedlex". https://www.fedlex.admin.ch/eli/cc/2011/363/de.
- ↑ "Misuse of Drugs Act 1971". 2021-08-15. https://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I.
pl:4-Acetoksy-N,N-dietylotryptamina
sv:4-acetoxy-DET
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