Chemistry:Antiglucocorticoid

Short description: Class of pharmaceutical drugs

Antiglucocorticoid
Drug class
Mifepristone, an antiglucocorticoid that is used in the treatment of Cushing's syndrome.
Class identifiers
Synonyms	Glucocorticoid antagonist; Cortisol antagonist; Anticorticosteroid
Use	Cushing's syndrome, others
Biological target	Glucocorticoid receptor
Chemical class	Steroids

An antiglucocorticoid is a drug which reduces glucocorticoid activity in the body. They include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, ketoconazole, and aminoglutethimide. They are used to treat Cushing's syndrome.

Antiglucocorticoids could be effective antidepressants for a subset of specific mood disorders, but their use is limited by side effects.

See also

• Corticosteroid
• Antimineralocorticoid