Chemistry:Lilopristone
From HandWiki
Short description: Chemical compound
 | |
| Clinical data | |
|---|---|
| Other names | ZK-98734; ZK-734; 11β-(4-(Dimethylamino)phenyl)-17β-hydroxy-17α-((Z)-3-hydroxypropenyl)estra-4,9-dien-3-one |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C29H37NO3 |
| Molar mass | 447.619 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Lilopristone (INN) (developmental code names ZK-98734, ZK-734) is a synthetic, steroidal antiprogestogen with additional antiglucocorticoid activity which was developed by Schering and was patented in 1985.[1][2][3][4] It is described as an abortifacient and endometrial contraceptive.[1][4][5] The drug differs from mifepristone only in the structure of its C17α side chain, and is said to have much reduced antiglucocorticoid activity in comparison.[6]
See also
References
- ↑ 1.0 1.1 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 733–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA733.
- ↑ Textbook of Gynaecology. Elsevier India. November 2009. pp. 187–. ISBN 978-81-312-1526-5. https://books.google.com/books?id=OzOq3Ddfg-8C&pg=PA187.
- ↑ Organ-Selective Actions of Steroid Hormones. Springer Science & Business Media. 9 March 2013. pp. 108–. ISBN 978-3-662-09153-1. https://books.google.com/books?id=sOUkBAAAQBAJ&pg=PA108.
- ↑ 4.0 4.1 Drugs: Synonyms and Properties: Synonyms and Properties. Taylor & Francis. 8 May 2018. pp. 23–. ISBN 978-1-351-78989-9. https://books.google.com/books?id=xUlaDwAAQBAJ&pg=PT23.
- ↑ Practical Management of Ovulation Induction. JP Medical Ltd. 12 February 2016. pp. 29–. ISBN 978-93-5250-028-4. https://books.google.com/books?id=GMMqCwAAQBAJ&pg=PA29.
- ↑ Contraceptive research and development, 1984 to 1994: the road from Mexico City to Cairo and beyond. Oxford University Press. 1994. p. 169. ISBN 978-0-19-563630-7. https://books.google.com/books?id=vg3bAAAAMAAJ. "[...] lilopristone, which differs from mifepristone only in the structure of the 17a side chain, is said to have a much reduced antiglucocorticoid activity (Neef et al., 1984)."
Further reading
- "Effects of progesterone antagonist, lilopristone (ZK 98.734), on induction of menstruation, inhibition of nidation, and termination of pregnancy in bonnet monkeys". Biology of Reproduction 43 (3): 437–43. September 1990. doi:10.1095/biolreprod43.3.437. PMID 2271724.
- "Progesterone antagonist lilopristone: a potent abortifacient in the common marmoset". American Journal of Obstetrics and Gynecology 161 (1): 248–53. July 1989. doi:10.1016/0002-9378(89)90274-3. PMID 2502015.
 |  |
