Chemistry:Chloroprednisone
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Short description: Topical glucocorticoid drug
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| Other names | 6α-Chloro-1,4-pregnadiene-17a,21-diol-3,11,20-trione |
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| Formula | C21H25ClO5 |
| Molar mass | 392.88 g·mol−1 |
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Chloroprednisone is a topical glucocorticoid first reported in 1960.[1] It is a chlorinated derivative of prednisone. The acetate ester prodrug, chloroprednisone 21-acetate, was sold under the brand name Topilan as an anti-inflammatory agent.[2][3]
There is little published about chloroprednisone. This may be due to limited activity topically because the skin lacks the necessary activating enzyme 11-Beta hydroxysteroid dehydrogenase. Systemically, this agent's activity on glucocorticoid receptors may not have competed with agents like fludrocortisone or dexamethasone.
References
- ↑ Batres E, Bowers A, Djerassi C, Kincl FA, Mancera O, Ringold HJ, Rosenkranz J, Zaffaroni A, "6α-Chloro- or 6α-fluoro-1,4-pregnadiene-3,20-diones.", DE patent 1079042, issued 1960.
- ↑ "2157: Chloroprednisone". The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th, centennial ed.). Rahway, N.J., U.S.A.: Merck. 1989. ISBN 978-0-911910-28-5.
- ↑ Dictionary of Steroids: Chemical Data, Structures, and Bibliographies. 1. CRC Press. 1991. p. 108.
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