Chemistry:Medrysone
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| Trade names | HMS, Medrocort, others |
| Other names | NSC-63278; Hydroxymethylprogesterone; Methylhydroxyprogesterone; Hydroxymesterone; 6α-Methyl-11β-hydroxyprogesterone; 6α-Methyl-11β-hydroxypregn-4-ene-3,20-dione |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| MedlinePlus | a606003 |
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| Routes of administration | Eye drops |
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| Chemical and physical data | |
| Formula | C22H32O3 |
| Molar mass | 344.495 g·mol−1 |
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Medrysone (INN, USAN) (brand names HMS, Medrocort, others; former developmental code name NSC-63278), also known as hydroxymethylprogesterone, methylhydroxyprogesterone, or hydroxymesterone, as well as 6α-methyl-11β-hydroxyprogesterone or 6α-methyl-11β-hydroxypregn-4-ene-3,20-dione, is a synthetic glucocorticoid that is or has been used in the treatment of inflammatory eye diseases.[1][2][3] It has been discontinued in the United States .[4] Although it is very similar in structure to progesterone,[5] neither progestogenic nor androgenic activity has been demonstrated for or attributed to medrysone.[6][7][8]
Environmental presence
In 2021, medrysone was one of the 12 compounds identified in sludge samples taken from 12 wastewater treatment plants in California that were associated with estrogenic activity in in vitro. [9]
See also
- 9α-Bromo-11-ketoprogesterone
- 11β-Hydroxyprogesterone
- Endrisone
- Flugestone
- Fluorometholone
References
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 760–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA760.
- ↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 640–. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA640.
- ↑ Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999. pp. 173–. ISBN 978-0-7514-0499-9. https://books.google.com/books?id=mqaOMOtk61IC&pg=PA173.
- ↑ "HMS - FDA prescribing information, side effects and uses". https://www.drugs.com/pro/hms.html.
- ↑ "The treatment of ocular inflammation with medrysone". Archives of Ophthalmology 81 (2): 184–191. February 1969. doi:10.1001/archopht.1969.00990010186008. PMID 5764682.
- ↑ "Hydroxymethylprogesterone. An anti-inflammatory steroid without apparent effect on intraocular pressure". Archives of Ophthalmology 75 (6): 783–787. June 1966. doi:10.1001/archopht.1966.00970050785014. PMID 5327794.
- ↑ "Topical anti-inflammatory steroids and intraocular pressure: the place of medrysone". Drugs 2 (1): 1–4. 1971. doi:10.2165/00003495-197102010-00001. PMID 5172545.
- ↑ "Medrysone hypersensitivity. Report of a case". Archives of Ophthalmology 85 (4): 478–479. April 1971. doi:10.1001/archopht.1971.00990050480015. PMID 5554878.
- ↑ "Using Estrogenic Activity and Nontargeted Chemical Analysis to Identify Contaminants in Sewage Sludge". Environmental Science & Technology 55 (10): 6729–6739. May 2021. doi:10.1021/acs.est.0c07846. PMID 33909413. Bibcode: 2021EnST...55.6729B.
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