Chemistry:Paramethasone acetate
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| Other names | Monocortin |
| Drug class | Corticosteroid; Glucocorticoid |
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| Formula | C24H31FO6 |
| Molar mass | 434.504 g·mol−1 |
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Paramethasone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is the acetate ester of paramethasone.[1][2]
Chemistry
Paramethasone acetate is the acetate ester derivative of paramethasone, a fluorinated glucocorticoid corticosteroid. It has the molecular formula C24H31FO6 and a molecular weight of 434.5 g/mol.[1][3]
Pharmacology
Paramethasone acetate is a synthetic glucocorticoid corticosteroid and the acetate ester of paramethasone. Like other glucocorticoids, it exerts anti-inflammatory and immunosuppressive effects by binding to glucocorticoid receptors and regulating the expression of genes involved in inflammatory and immune responses.[1][3]
Names and identifiers
Paramethasone acetate has been marketed under the trade name Monocortin. The compound has the CAS Registry Number 1597-82-6 and is listed in several chemical and pharmaceutical databases, including PubChem, DrugBank, ChEBI, and KEGG.[1]
History
Paramethasone acetate was developed as a synthetic glucocorticoid corticosteroid during the expansion of corticosteroid drug research in the mid-twentieth century. The drug was marketed under trade names including Monocortin and Haldrone and was in clinical use by the early 1970s, when studies evaluating injectable formulations were published.[4]
According to pharmaceutical reference databases, paramethasone acetate was originally developed by Eli Lilly and received approval in the United States in 1961.[5]
References
- ↑ 1.0 1.1 1.2 1.3 PubChem. "Paramethasone Acetate" (in en). https://pubchem.ncbi.nlm.nih.gov/compound/443928.
- ↑ PubChem. "Paramethasone acetate (JAN/USAN)" (in en). https://pubchem.ncbi.nlm.nih.gov/substance/7848292.
- ↑ 3.0 3.1 "Compound: PARAMETHASONE ACETATE (CHEMBL1200342)". https://www.ebi.ac.uk/explore/compound/CHEMBL1200342.
- ↑ "KEGG DRUG: Paramethasone acetate". https://www.kegg.jp/entry/D01229.
- ↑ "Delving into the Latest Updates on Paramethasone Acetate with Synapse" (in en). https://synapse.patsnap.com/drug/000133a233844135a2994ad3dbd3c76f.
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