Chemistry:Flugestone acetate
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| Clinical data | |
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| Trade names | Cronolone, others |
| Other names | Flurogestone acetate; Fluorogestone acetate; FGA; NSC-65411; SC-9880; 17α-Acetoxy-9α-fluoro-11β-hydroxyprogesterone |
| Routes of administration | Intravaginal |
| Drug class | Progestogen; Progestin; Progestogen ester |
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| Chemical and physical data | |
| Formula | C23H31FO5 |
| Molar mass | 406.494 g·mol−1 |
| 3D model (JSmol) | |
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Flugestone acetate (FGA), sold under the brand name Cronolone among others, is a progestin medication which is used in veterinary medicine.[1][2][3][4][5][6]
Uses
Veterinary
FGA is used as an intravaginal sponge preparation to synchronize estrus in ewes and goats.[2][4][5][6]
Chemistry
FGA, also known as 17α-acetoxy-9α-fluoro-11β-hydroxyprogesterone or as 17α-acetoxy-9α-fluoro-11β-hydroxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone.[1][3] It is the C17α acetate ester of flugestone.[1][3][2]
History
FGA was developed and marketed by G.D. Searle & Company in the 1960s.[7][8]
Society and culture
Generic names
Flugestone acetate is the generic name of the drug and its INN and BANM, while flurogestone acetate is its USAN.[1][3][2][9] Flugestone is the BAN and DCIT of the unesterified free alcohol form.[1][3][2][9] FGA is also known by its developmental code names NSC-65411 and SC-9880.[1][3][2][9]
Brand names
FGA is or has been marketed under the brand names Chronogest, Chrono-Gest, Crono-Gest, Cronolone, Gyncro-Mate, Ova-Gest, Ovakron, Synchro-Mate, Syncro Part, and Syncropart.[1][3][2][9]
Availability
FGA is marketed for veterinary use in Australia , France , Ireland, Israel, Italy, the Netherlands, South Africa , and the United Kingdom .[3][9]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 559. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA559.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999. pp. 122–. ISBN 978-0-7514-0499-9. https://books.google.com/books?id=mqaOMOtk61IC&pg=PA122.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 451–. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA451.
- ↑ 4.0 4.1 Office of the Federal Register (US) (29 May 2012). Code of Federal Regulations Title 21: Food and Drug Administration: Parts 500-599, Revised April 1, 2012. Government Printing Office. pp. 359–. ISBN 978-0-16-090718-0. https://books.google.com/books?id=qgaa_aamvV0C&pg=PA359.
- ↑ 5.0 5.1 Current Therapy in Large Animal Theriogenology. Elsevier Health Sciences. 23 November 2006. pp. 2640–. ISBN 1-4377-1340-8. https://books.google.com/books?id=7qogKGcOENAC&pg=PT2640.
- ↑ 6.0 6.1 Saunders Comprehensive Veterinary Dictionary. Elsevier Health Sciences. 9 December 2011. pp. 2673–. ISBN 978-0-7020-4744-2. https://books.google.com/books?id=6dvQAQAAQBAJ&pg=PT2673.
- ↑ Animal Husbandry Research: Reports on Agricultural Industry. 1967. p. 60. https://books.google.com/books?id=47kOAQAAMAAJ.
- ↑ Dairy Science Handbook. Agriservices Foundation. 1971. p. 10. https://books.google.com/books?id=mO0qAQAAMAAJ.
- ↑ 9.0 9.1 9.2 9.3 9.4 "Flugestone". Drugs.com. https://www.drugs.com/international/flugestone.html.
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