Biology:KIF2C
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.[1][2]
The protein encoded by this gene is a member of kinesin-like protein family, and contains common ATPase site structures such as the P-loop, Switch 1, and Switch 2.[3] Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.[2]
References
- ↑ "Cloning and expression of human mitotic centromere-associated kinesin gene". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1359 (3): 181–186. December 1997. doi:10.1016/s0167-4889(97)00103-1. PMID 9434124.
- ↑ 2.0 2.1 "Entrez Gene: KIF2C kinesin family member 2C". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=11004.
- ↑ "Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin". Nature Communications 8 (1): 70. July 2017. doi:10.1038/s41467-017-00091-9. PMID 28694425.
- ↑ "RCSB PDB - 3EDL: Kinesin13-Microtubule Ring complex" (in en-US). RCSB Protein Data Bank. https://www.rcsb.org/structure/3EDL.
Further reading
- "All kinesin superfamily protein, KIF, genes in mouse and human". Proceedings of the National Academy of Sciences of the United States of America 98 (13): 7004–7011. June 2001. doi:10.1073/pnas.111145398. PMID 11416179. Bibcode: 2001PNAS...98.7004M.
- "Mitotic centromere-associated kinesin is important for anaphase chromosome segregation". The Journal of Cell Biology 142 (3): 787–801. August 1998. doi:10.1083/jcb.142.3.787. PMID 9700166.
- "Mutations in the ATP-binding domain affect the subcellular distribution of mitotic centromere-associated kinesin (MCAK)". Cell Biology International 23 (4): 275–286. 2000. doi:10.1006/cbir.1999.0359. PMID 10600236.
- "Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes". Human Molecular Genetics 9 (19): 2919–2926. November 2000. doi:10.1093/hmg/9.19.2919. PMID 11092768.
- "Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin". The Journal of Biological Chemistry 276 (37): 34753–34758. September 2001. doi:10.1074/jbc.M106626200. PMID 11466324.
- "Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis". Life Sciences 71 (23): 2741–2757. October 2002. doi:10.1016/S0024-3205(02)02079-9. PMID 12383881.
- "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly". Molecular Biology of the Cell 15 (4): 1580–1590. April 2004. doi:10.1091/mbc.E03-07-0544. PMID 14718566.
- "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK". The Journal of Cell Biology 166 (4): 473–478. August 2004. doi:10.1083/jcb.200404012. PMID 15302853.
- "MCAK, a Kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitro". FEBS Letters 572 (1–3): 80–84. August 2004. doi:10.1016/j.febslet.2004.06.093. PMID 15304328.
- "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. January 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "MCAK associates with the tips of polymerizing microtubules". The Journal of Cell Biology 169 (3): 391–397. May 2005. doi:10.1083/jcb.200411089. PMID 15883193.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Efficient mitosis in human cells lacking poleward microtubule flux". Current Biology 15 (20): 1827–1832. October 2005. doi:10.1016/j.cub.2005.08.065. PMID 16243029. Bibcode: 2005CBio...15.1827G.
- "The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends". Nature 441 (7089): 115–119. May 2006. doi:10.1038/nature04736. PMID 16672973. Bibcode: 2006Natur.441..115H.
- "HIV-1 Tat depresses DNA-PK(CS) expression and DNA repair, and sensitizes cells to ionizing radiation". International Journal of Radiation Oncology, Biology, Physics 65 (3): 842–850. July 2006. doi:10.1016/j.ijrobp.2006.02.040. PMID 16751065.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. November 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
External links
- Overview of all the structural information available in the PDB for UniProt: Q99661 (Kinesin-like protein KIF2C) at the PDBe-KB.
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