Biology:Keratin 10
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene.[1][2][3] Keratin 10 is a type I keratin.
Function
Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.[3]
Interactions
Keratin 10 has been shown to interact with AKT1.[4]
See also
- 34βE12 (keratin 903)
References
- ↑ "Chromosomal mapping of human keratin genes: evidence of non-linkage". J Invest Dermatol 91 (6): 572–8. Jan 1989. doi:10.1111/1523-1747.ep12477087. PMID 2461420.
- ↑ "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. Jul 2006. doi:10.1083/jcb.200603161. PMID 16831889.
- ↑ 3.0 3.1 "Entrez Gene: KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3858.
- ↑ Paramio, J M; Segrelles C; Ruiz S; Jorcano J L (Nov 2001). "Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest". Mol. Cell. Biol. (United States) 21 (21): 7449–59. doi:10.1128/MCB.21.21.7449-7459.2001. ISSN 0270-7306. PMID 11585925.
Further reading
- "Arginine in the beginning of the 1A rod domain of the keratin 10 gene is the hot spot for the mutation in epidermolytic hyperkeratosis". J. Dermatol. Sci. 19 (2): 126–33. 1999. doi:10.1016/S0923-1811(98)00055-3. PMID 10098704.
- "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis 13 (12): 960–9. 1993. doi:10.1002/elps.11501301199. PMID 1286667.
- "Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops". Proc. Natl. Acad. Sci. U.S.A. 89 (3): 910–4. 1992. doi:10.1073/pnas.89.3.910. PMID 1371013. Bibcode: 1992PNAS...89..910K.
- "Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats". Gene 116 (2): 245–51. 1992. doi:10.1016/0378-1119(92)90521-P. PMID 1378806.
- "Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis". Science 257 (5073): 1128–30. 1992. doi:10.1126/science.257.5073.1128. PMID 1380725. Bibcode: 1992Sci...257.1128R.
- "The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes". Cell 70 (5): 811–9. 1992. doi:10.1016/0092-8674(92)90314-3. PMID 1381287.
- "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. 1992. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
- "Epidermolytic hyperkeratosis: generalized form in children from parents with systematized linear form". Br. J. Dermatol. 122 (3): 417–22. 1990. doi:10.1111/j.1365-2133.1990.tb08292.x. PMID 2182100.
- "Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression". Mol. Biol. Rep. 12 (4): 277–83. 1988. doi:10.1007/BF00444680. PMID 2448602.
- "The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences". J. Biol. Chem. 263 (30): 15584–9. 1988. doi:10.1016/S0021-9258(19)37628-8. PMID 2459124.
- "Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10". J. Mol. Biol. 204 (4): 841–56. 1989. doi:10.1016/0022-2836(88)90045-9. PMID 2464696.
- "Anti-tumor and differentiation-inducing activity of N,N-dimethylformamide (DMF) in head-and-neck cancer xenografts". Int. J. Cancer 43 (2): 285–92. 1989. doi:10.1002/ijc.2910430221. PMID 2465278.
- "Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes". Nat. Genet. 5 (2): 158–62. 1994. doi:10.1038/ng1093-158. PMID 7504553.
- "Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing". J. Invest. Dermatol. 102 (1): 13–6. 1994. doi:10.1111/1523-1747.ep12371723. PMID 7507150.
- "Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE)". J. Invest. Dermatol. 102 (1): 24–30. 1994. doi:10.1111/1523-1747.ep12371726. PMID 7507152.
- "Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis". Am. J. Hum. Genet. 54 (2): 179–90. 1994. PMID 7508181.
- "A mutational hot spot in keratin 10 (KRT 10) in patients with epidermolytic hyperkeratosis". Hum. Mol. Genet. 2 (12): 2147–50. 1994. doi:10.1093/hmg/2.12.2147. PMID 7509230. http://doc.rero.ch/record/292325/files/2-12-2147.pdf.
- "Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity". J. Clin. Invest. 93 (4): 1533–42. 1994. doi:10.1172/JCI117132. PMID 7512983.
- "Abnormal keratin 1 and 10 cytoskeleton in cultured keratinocytes from epidermolytic hyperkeratosis caused by keratin 10 mutations". J. Invest. Dermatol. 102 (5): 691–4. 1994. doi:10.1111/1523-1747.ep12374270. PMID 7513736.
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