Biology:KIF18A
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Kinesin family member KIF18A is a human protein encoded by the KIF18A gene.[1][2] It is part of the kinesin family of motor proteins.
Function
KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted during anaphase.[3]
KIF18a(-/-) knockout in mice results in complete sterility in males, but not females, due to abnormal development of the seminiferous tubules.[4] The mice were otherwise normal, suggesting KIF18a is not essential for cell divisions in non-germ cells.
Therapeutic Target
KIF18A has been considered as a cancer target because it is overexpressed in many cancer types and mouse studies suggest it is dispensable in somatic cells.[5] As such, small molecule inhibitors of KIF18A have been developed to block its activity. [5]
References
- ↑ "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–435. March 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- ↑ "Entrez Gene: KIF18A kinesin family member 18A". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=81930.
- ↑ "The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression" (in English). Current Biology 17 (6): 488–498. March 2007. doi:10.1016/j.cub.2007.02.036. PMID 17346968. Bibcode: 2007CBio...17..488M.
- ↑ "Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E". Genes & Cancer 1 (1): 26–39. January 2010. doi:10.1177/1947601909358184. PMID 20981276.
- ↑ 5.0 5.1 "Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers". Nature Cancer 5 (1): 66–84. January 2024. doi:10.1038/s43018-023-00699-5. PMID 38151625.
Further reading
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–1795. November 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–16903. December 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics 36 (1): 40–45. January 2004. doi:10.1038/ng1285. PMID 14702039.
- "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology 6 (2): 97–105. February 2004. doi:10.1038/ncb1086. PMID 14743216.
- "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–1332. July 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research 14 (10B): 2121–2127. October 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–2144. October 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "MS-KIF18A, new kinesin; structure and cellular expression". Gene 351: 19–28. May 2005. doi:10.1016/j.gene.2005.02.009. PMID 15878648.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. January 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–D418. January 2006. doi:10.1093/nar/gkj139. PMID 16381901.
- "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–5396. April 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Kinesin-like protein KIF18A
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