Biology:KIF2A
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene.[1][2] In mice, KIF2A is essential for proper neurogenesis and deficiency of KIF2A in mature neurons results in the loss of those neurons.[3]
Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM][2]
References
- ↑ "Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique". Genomics 42 (1): 67–73. May 1997. doi:10.1006/geno.1997.4720. PMID 9177777.
- ↑ 2.0 2.1 "Entrez Gene: KIF2A kinesin heavy chain member 2A". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3796.
- ↑ "KIF2A deficiency causes early-onset neurodegeneration". Proceedings of the National Academy of Sciences of the United States of America 119 (46). November 2022. doi:10.1073/pnas.2209714119. PMID 36343267. Bibcode: 2022PNAS..11909714R.
Further reading
- "The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells". Molecular Biology of the Cell 18 (8): 2970–2979. August 2007. doi:10.1091/mbc.E07-02-0110. PMID 17538014.
- "Kinesin-1 plays multiple roles during the vaccinia virus life cycle". Cellular Microbiology 9 (8): 1960–1973. August 2007. doi:10.1111/j.1462-5822.2007.00927.x. PMID 17394562.
- "A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia". Neuroscience Letters 407 (2): 151–155. October 2006. doi:10.1016/j.neulet.2006.08.025. PMID 16959419.
- "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–5396. April 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
- "Efficient mitosis in human cells lacking poleward microtubule flux". Current Biology 15 (20): 1827–1832. October 2005. doi:10.1016/j.cub.2005.08.065. PMID 16243029. Bibcode: 2005CBio...15.1827G.
- "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK". The Journal of Cell Biology 166 (4): 473–478. August 2004. doi:10.1083/jcb.200404012. PMID 15302853.
- "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science 302 (5653): 2141–2144. December 2003. doi:10.1126/science.1090100. PMID 14684825. Bibcode: 2003Sci...302.2141J.
External links
- Overview of all the structural information available in the PDB for UniProt: O00139 (Human Kinesin-like protein KIF2A) at the PDBe-KB.
PDB gallery | |
|---|---|
|
 |  |
