Biology:Keratin 13

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example


Keratin 13 (or cytokeratin 13) is a protein that in humans is encoded by the KRT13 gene.[1][2]

Keratin 13 is a type I cytokeratin, it is paired with keratin 4 and found in the suprabasal layers of non-cornified stratified epithelia. Mutations in the gene encoding this protein and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.[3]

References

  1. "Chromosomal mapping of human cytokeratin 13 gene (KRT13)". Genomics 14 (2): 495–7. October 1992. doi:10.1016/S0888-7543(05)80250-2. PMID 1385306. 
  2. "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. July 2006. doi:10.1083/jcb.200603161. PMID 16831889. 
  3. "Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus". Nat. Genet. 11 (4): 453–5. December 1995. doi:10.1038/ng1295-453. PMID 7493031. https://zenodo.org/record/1233409. 

Further reading