Chemistry:6-Chloronicotine
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Short description: Chemical compound
-6-Chloronicotine.svg) | |
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| Formula | C10H13ClN2 |
| Molar mass | 196.68 g·mol−1 |
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6-Chloronicotine is a drug which acts as an agonist at neural nicotinic acetylcholine receptors. It substitutes for nicotine in animal studies with around twice the potency, and shows antinociceptive effects.[1][2][3][4]
See also
References
- ↑ "Pyrrolidine-modified and 6-substituted analogs of nicotine: A structure—affinity investigation.". European Journal of Medicinal Chemistry 31 (11): 875–888. 1996. doi:10.1016/S0223-5234(97)89850-9.
- ↑ "Antinociceptive responses to nicotinic acetylcholine receptor ligands after systemic and intrathecal administration in mice". The Journal of Pharmacology and Experimental Therapeutics 284 (3): 1058–65. March 1998. PMID 9495867.
- ↑ "Synthesis, receptor binding and QSAR studies on 6-substituted nicotine derivatives as cholinergic ligands.". European Journal of Medicinal Chemistry 34 (1): 31–40. 1999. doi:10.1016/S0223-5234(99)80038-5.
- ↑ "Novel and potent 6-chloro-3-pyridinyl ligands for the alpha4beta2 neuronal nicotinic acetylcholine receptor". Journal of Medicinal Chemistry 42 (12): 2227–34. June 1999. doi:10.1021/jm980721x. PMID 10377228.
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