Chemistry:PNU-120,596
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Short description: Chemical compound
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| Formula | C13H14ClN3O4 |
| Molar mass | 311.720 g·mol−1 |
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PNU-120596 is a drug that acts as a potent and selective positive allosteric modulator for the α7 subtype of neural nicotinic acetylcholine receptors.[1][2] It is used in scientific research into cholinergic regulation of dopamine and glutamate release in the brain.[3][4][5]
References
- ↑ "A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization". The Journal of Neuroscience 25 (17): 4396–405. April 2005. doi:10.1523/JNEUROSCI.5269-04.2005. PMID 15858066.
- ↑ "Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site". Proceedings of the National Academy of Sciences of the United States of America 105 (38): 14686–91. September 2008. doi:10.1073/pnas.0804372105. PMID 18791069. Bibcode: 2008PNAS..10514686Y.
- ↑ "alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate dopamine release in vitro and in vivo in the rat prefrontal cortex". The European Journal of Neuroscience 29 (3): 539–50. February 2009. doi:10.1111/j.1460-9568.2009.06613.x. PMID 19187266. https://www.openaccessrepository.it/record/22342.
- ↑ "An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine". Molecular Pharmacology 76 (2): 253–63. August 2009. doi:10.1124/mol.109.056226. PMID 19411608.
- ↑ "Glutamate-dopamine crosstalk in the rat prefrontal cortex is modulated by Alpha7 nicotinic receptors and potentiated by PNU-120596". Journal of Molecular Neuroscience 40 (1–2): 172–6. January 2010. doi:10.1007/s12031-009-9232-5. PMID 19688191.
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