Chemistry:AM-0902

AM-0902
Identifiers
	IUPAC name 1-({3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl}methyl)-7-methylpurin-6-one;
CAS Number	1883711-97-4 ;
PubChem CID	73297271;
ChemSpider	58864849;
UNII	3E4SQ96PCJ;
ChEMBL	ChEMBL3785736;
Chemical and physical data
Formula	C17H15ClN6O2
Molar mass	370.80 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1C=NC2=C1C(=O)N(C=N2)CC3=NC(=NO3)CCC4=CC=C(C=C4)Cl;
	InChI InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3; Key:AWJBWNUUODWOKQ-UHFFFAOYSA-N;

Short description: Chemical compound

AM-0902 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor, and has analgesic and antiinflammatory effects.^[1]^[2]

References

↑ "Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity". Journal of Medicinal Chemistry 59 (6): 2794–809. March 2016. doi:10.1021/acs.jmedchem.6b00039. PMID 26942860.
↑ "Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain". Journal of Neurochemistry 149 (3): 381–398. May 2019. doi:10.1111/jnc.14677. PMID 30716174.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/AM-0902. Read more

Identifiers

IUPAC name 1-({3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl}methyl)-7-methylpurin-6-one
CAS Number	1883711-97-4^Y
PubChem CID	73297271
ChemSpider	58864849
UNII	3E4SQ96PCJ
ChEMBL	ChEMBL3785736
Chemical and physical data
Formula	C₁₇H₁₅ClN₆O₂
Molar mass	370.80 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN1C=NC2=C1C(=O)N(C=N2)CC3=NC(=NO3)CCC4=CC=C(C=C4)Cl
InChI InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3 Key:AWJBWNUUODWOKQ-UHFFFAOYSA-N