Chemistry:JWH-147
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Short description: Chemical compound
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| Formula | C27H27NO |
| Molar mass | 381.519 g·mol−1 |
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JWH-147 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 11.0 nM at CB1 vs 7.1 nM at CB2.[1] It was discovered and named after the renowned professor of organic chemistry John W. Huffman.
Legal status
In the United States, CB1 receptor agonists of the 3-(1-naphthoyl)pyrrole class such as JWH-147 are Schedule I Controlled Substances.[2]
JWH-147 was banned in Sweden on 1 October 2010 as harmful to health, after being identified as an ingredient in "herbal" synthetic cannabis products.[3][4]
See also
References
- ↑ "1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors". Bioorganic & Medicinal Chemistry Letters 16 (20): 5432–5. October 2006. doi:10.1016/j.bmcl.2006.07.051. PMID 16889960.
- ↑ : Schedules of controlled substances
- ↑ Swedish Code of Statutes Regulation (2010:1086).
- ↑ "Swedish Code of Statutes Regulation (2010:1086). (pdf)". http://www.lagboken.se/files/SFS/2010/101086.PDF.
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