Chemistry:JT-010
From HandWiki
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| Preferred IUPAC name
2-Chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide | |
| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C16H19ClN2O3S | |
| Molar mass | 354.85 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
JT-010 is a chemical compound which acts as a potent, selective activator of the TRPA1 channel, and has been used to study the role of this receptor in the perception of pain, as well as other actions such as promoting repair of dental tissue after damage.[1][2][3][4]
See also
References
- ↑ "A Potent and Site-Selective Agonist of TRPA1". Journal of the American Chemical Society 137 (50): 15859–64. December 2015. doi:10.1021/jacs.5b10162. PMID 26630251.
- ↑ "A Human TRPA1-Specific Pain Model". The Journal of Neuroscience 39 (20): 3845–3855. May 2019. doi:10.1523/JNEUROSCI.3048-18.2019. PMID 30862667.
- ↑ "Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel". Neuron 105 (5): 882–894.e5. March 2020. doi:10.1016/j.neuron.2019.11.023. PMID 31866091.
- ↑ "Transient Receptor Potential Ankyrin 1 Is Up-Regulated in Response to Lipopolysaccharide via P38/Mitogen-Activated Protein Kinase in Dental Pulp Cells and Promotes Mineralization". The American Journal of Pathology 190 (12): 2417–2426. September 2020. doi:10.1016/j.ajpath.2020.08.016. PMID 32919979.
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