Chemistry:Vinorine
From HandWiki
Vinorine is an indole alkaloid isolated from Alstonia.[1] It is produced in trees in the Rauvolfia genus by the enzyme vinorine synthase.[2][3][4]
References
- ↑ Cao, P.; Liang, Y.; Gao, X.; Li, X. M.; Song, Z. Q.; Liang, G. (2012). "Monoterpenoid indole alkaloids from Alstonia yunnanensis and their cytotoxic and anti-inflammatory activities". Molecules (Basel, Switzerland) 17 (11): 13631–41. doi:10.3390/molecules171113631. PMID 23159924.
- ↑ "Acetyltransfer in natural product biosynthesis--functional cloning and molecular analysis of vinorine synthase". Bioorg. Med. Chem. 12 (10): 2787–95. 2004. doi:10.1016/j.bmc.2004.02.029. PMID 15110860.
- ↑ Stockigt J; Koepke, J; Bayer, A; Linhard, V; Fritzsch, G; Zhang, B; Michel, H; Stöckigt, J (2004). "Vinorine synthase from Rauvolfia: the first example of crystallization and preliminary X-ray diffraction analysis of an enzyme of the BAHD superfamily". Biochim. Biophys. Acta 1701 (1–2): 129–32. doi:10.1016/j.bbapap.2004.06.011. PMID 15450182.
- ↑ "Crystal structure of vinorine synthase, the first representative of the BAHD superfamily". J. Biol. Chem. 280 (14): 13576–83. 2005. doi:10.1074/jbc.M414508200. PMID 15665331.
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