Biology:Agmatinase
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
| agmatinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 agmatinase hexamer, Deinococcus radiodurans | |||||||||
| Identifiers | |||||||||
| EC number | 3.5.3.11 | ||||||||
| CAS number | 37289-16-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an agmatinase (EC 3.5.3.11) is an enzyme that catalyzes the chemical reaction
- agmatine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] putrescine + urea
Thus, the two substrates of this enzyme are agmatine and H2O, whereas its two products are putrescine and urea.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is agmatine amidinohydrolase. Other names in common use include agmatine ureohydrolase, and SpeB. This enzyme participates in urea cycle and metabolism of amino groups.
Genetics
 Generic protein structure example |
In humans, the enzyme is encoded by the AGMAT gene.[1][2][3][4]
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1GQ6, 1GQ7, 1WOG, 1WOH, and 1WOI.
Inhibitors
- Piperazine-1-carboxamidine
References
- ↑ "Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus". Am J Physiol Gastrointest Liver Physiol 282 (2): G375–81. Jan 2002. doi:10.1152/ajpgi.00386.2001. PMID 11804860.
- ↑ "Human agmatinase is diminished in the clear cell type of renal cell carcinoma". Int J Cancer 108 (3): 342–7. Dec 2003. doi:10.1002/ijc.11459. PMID 14648699.
- ↑ "Cloning and characterization of human agmatinase". Mol Genet Metab 75 (3): 209–18. Mar 2002. doi:10.1006/mgme.2001.3277. PMID 11914032.
- ↑ "Entrez Gene: AGMAT agmatine ureohydrolase (agmatinase)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79814.
- Morris SM (2004). "Vertebrate agmatinases: what role do they play in agmatine catabolism?". Ann. N. Y. Acad. Sci. 1009: 30–3. doi:10.1196/annals.1304.003. PMID 15028567.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Differential gene expression in apoptosis: identification of ribosomal protein 23K, a cell proliferation inhibitor". Mol. Genet. Metab. 64 (4): 271–82. 1998. doi:10.1006/mgme.1998.2718. PMID 9758718.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Expression, crystallization and preliminary X-ray crystallographic analysis of human agmatinase". Acta Crystallographica Section F 61 (Pt 10): 889–91. 2006. doi:10.1107/S1744309105027193. PMID 16511187.
- "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "Isolation and Characterization of a Mutant of Escherichia coli Blocked in the Synthesis of Putrescine". J. Bacteriol. 101 (3): 725–30. 1970. doi:10.1128/JB.101.3.725-730.1970. PMID 4908780.
- "Preparation and properties of agmatine amidinohydrolase of Evernia prunastri". Physiol. Plant. 55: 335–339. 1982. doi:10.1111/j.1399-3054.1982.tb00301.x.
- agmatinase at the US National Library of Medicine Medical Subject Headings (MeSH)
External links
- Human AGMAT genome location and AGMAT gene details page in the UCSC Genome Browser.
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