Biology:KIF2C
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.[1][2]
The protein encoded by this gene is a member of kinesin-like protein family. Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.[2]
References
- ↑ "Cloning and expression of human mitotic centromere-associated kinesin gene". Biochim Biophys Acta 1359 (3): 181–6. Feb 1998. doi:10.1016/s0167-4889(97)00103-1. PMID 9434124.
- ↑ 2.0 2.1 "Entrez Gene: KIF2C kinesin family member 2C". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11004.
Further reading
- "All kinesin superfamily protein, KIF, genes in mouse and human". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004–11. 2001. doi:10.1073/pnas.111145398. PMID 11416179. Bibcode: 2001PNAS...98.7004M.
- "Mitotic Centromere–associated Kinesin Is Important for Anaphase Chromosome Segregation". J. Cell Biol. 142 (3): 787–801. 1998. doi:10.1083/jcb.142.3.787. PMID 9700166.
- "Mutations in the ATP-binding domain affect the subcellular distribution of mitotic centromere-associated kinesin (MCAK)". Cell Biol. Int. 23 (4): 275–86. 2000. doi:10.1006/cbir.1999.0359. PMID 10600236.
- "Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes". Hum. Mol. Genet. 9 (19): 2919–26. 2001. doi:10.1093/hmg/9.19.2919. PMID 11092768.
- "Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin". J. Biol. Chem. 276 (37): 34753–8. 2001. doi:10.1074/jbc.M106626200. PMID 11466324.
- "Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis". Life Sci. 71 (23): 2741–57. 2002. doi:10.1016/S0024-3205(02)02079-9. PMID 12383881.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "TOGp, the Human Homolog of XMAP215/Dis1, Is Required for Centrosome Integrity, Spindle Pole Organization, and Bipolar Spindle Assembly". Mol. Biol. Cell 15 (4): 1580–90. 2004. doi:10.1091/mbc.E03-07-0544. PMID 14718566.
- "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK". J. Cell Biol. 166 (4): 473–8. 2004. doi:10.1083/jcb.200404012. PMID 15302853.
- "MCAK, a Kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitro". FEBS Lett. 572 (1–3): 80–4. 2004. doi:10.1016/j.febslet.2004.06.093. PMID 15304328.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "MCAK associates with the tips of polymerizing microtubules". J. Cell Biol. 169 (3): 391–7. 2005. doi:10.1083/jcb.200411089. PMID 15883193.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Efficient mitosis in human cells lacking poleward microtubule flux". Curr. Biol. 15 (20): 1827–32. 2006. doi:10.1016/j.cub.2005.08.065. PMID 16243029.
- "The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends". Nature 441 (7089): 115–9. 2006. doi:10.1038/nature04736. PMID 16672973. Bibcode: 2006Natur.441..115H.
- "HIV-1 Tat depresses DNA-PK(CS) expression and DNA repair, and sensitizes cells to ionizing radiation". Int. J. Radiat. Oncol. Biol. Phys. 65 (3): 842–50. 2006. doi:10.1016/j.ijrobp.2006.02.040. PMID 16751065.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
External links
- Overview of all the structural information available in the PDB for UniProt: Q99661 (Kinesin-like protein KIF2C) at the PDBe-KB.
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