Chemistry:Anidoxime
From HandWiki
Anidoxime was an experimental drug that had been evaluated for use as an oral analgesic.[1][2]
The name is an eponym of an anisdine group and an oxime. The analgesic properties are reportedly equipotent to or greater than morphine but the physical dependence liability may be less.[3]
In rats, the major metabolic pathway is hydrolysis of the carbamoyl group followed by decarboxylation.[4]
References
- ↑ "Anidoxime: a clinical trial of an oral analgesic agent". British Journal of Anaesthesia 49 (3): 257–8. March 1977. doi:10.1093/bja/49.3.257. PMID 334207.
- ↑ "Anidoxime hydrochloride". Drugs of the Future 3 (3): 173. 1978. doi:10.1358/dof.1978.003.03.1000263.
- ↑ "Comparative analgesic, behavioral, and dependence properties of morphine and O-(4-methoxylphenylcarbamoyl)-3-diethylaminopropiophenone oxime hydrochloride". Journal of Pharmaceutical Sciences 69 (2): 225–6. February 1980. doi:10.1002/jps.2600690234. PMID 7188962.
- ↑ "Tissue distribution and metabolism of O-(4-methoxyphenylcarbamoyl)-3-diethylaminopropiophenone oxime hydrochloride (USVP-E142) in the rat.". Journal of Applied Toxicology 2 (1): 21–26. February 1982. doi:10.1002/jat.2550020106.
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