Chemistry:PF-05089771

PF-05089771
Legal status
Legal status	US: Investigational New Drug ;
Identifiers
	IUPAC name 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzene-1-sulfonamide;
CAS Number	1235403-62-9;
PubChem CID	46840946;
ChemSpider	29411106;
UNII	25U4N985O2;
ChEMBL	ChEMBL2325014;
Chemical and physical data
Formula	C18H12Cl2FN5O3S2
Molar mass	500.34 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=C(C=C1Cl)C2=C(NN=C2)N)OC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=CSC=N4)F;
	InChI InChI=1S/C18H12Cl2FN5O3S2/c19-9-1-2-14(10(3-9)11-6-24-25-18(11)22)29-15-5-13(21)16(4-12(15)20)31(27,28)26-17-7-30-8-23-17/h1-8,26H,(H3,22,24,25); Key:ZYSCOUXLBXGGIM-UHFFFAOYSA-N;

Short description: Investigational analgesic drug

PF-05089771 is a selective, small-molecule Na_v1.7 and Na_v1.8 voltage-gated sodium channel blocker under development by Pfizer as a novel analgesic.^[1]^[2]^[3] As of June 2014, it has completed phase II clinical trials for wisdom tooth removal and primary erythromelalgia.^[4]

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Legal status

Legal status	US: Investigational New Drug
Identifiers
IUPAC name 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzene-1-sulfonamide
CAS Number	1235403-62-9
PubChem CID	46840946
ChemSpider	29411106
UNII	25U4N985O2
ChEMBL	ChEMBL2325014
Chemical and physical data
Formula	C₁₈H₁₂Cl₂FN₅O₃S₂
Molar mass	500.34 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC(=C(C=C1Cl)C2=C(NN=C2)N)OC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=CSC=N4)F
InChI InChI=1S/C18H12Cl2FN5O3S2/c19-9-1-2-14(10(3-9)11-6-24-25-18(11)22)29-15-5-13(21)16(4-12(15)20)31(27,28)26-17-7-30-8-23-17/h1-8,26H,(H3,22,24,25) Key:ZYSCOUXLBXGGIM-UHFFFAOYSA-N