Chemistry:Meptazinol
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Meptazinol, sold under the brand name Meptid, is an opioid analgesic developed by Wyeth in the 1970s.[1] Indications for use in moderate to severe pain, most commonly used to treat pain in obstetrics (childbirth).
Meptazinol is a 3-phenylazepane derivative, whereas the other phenazepanes like ethoheptazine and proheptazine are 4-phenylazepanes.
A partial μ-opioid receptor agonist, its mixed agonist/antagonist activity affords it a lower risk of dependence and abuse than full μ agonists like morphine. Meptazinol exhibits not only a short onset of action, but also a shorter duration of action relative to other opioids such as morphine, pentazocine, or buprenorphine.[2]
Review:[3]
References
- ↑ Cavalla JF, Shepherd RG, White AC, "Hexahydroazepine, Piperidine and Pyrrolidine Derivatives", US patent 4197239, issued 1980-04-08, assigned to Wyeth
- ↑ "Meptazinol. A Review of its Pharmacodynamic and Pharmacokinetic Properties and Therapeutic Efficacy". Drugs 30 (4): 285–312. 1985. doi:10.2165/00003495-198530040-00001. PMID 2998723.
- ↑ "Meptazinol". Drugs of the Future 1 (2): 68. 1976. doi:10.1358/dof.1976.001.02.277280.
External links
- Meptazinol at the US National Library of Medicine Medical Subject Headings (MeSH)
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| DOR |
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| NOP |
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