Chemistry:Nicodicodine
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Short description: Opioid antitussive and analgesic drug
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| Other names | Nicodicodeine, 6-Nicotinoyldihydrocodeine, Nicodicodina,[1] Nicodicodinum[1] |
| Routes of administration | Oral, intravenous |
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| Formula | C24H26N2O4 |
| Molar mass | 406.482 g·mol−1 |
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Nicodicodine is an opioid developed as a cough suppressant and analgesic.[7] Synthesized in 1904, it is not commonly used, but has activity similar to other opioids.[7] Nicodicodine is metabolised in the liver by demethylation to produce 6-nicotinoyldihydromorphine, and subsequently further metabolised to dihydromorphine. Since the final active metabolite is the slightly stronger opiate dihydromorphine rather than morphine, nicodicodine can be expected to be marginally more potent and longer acting than nicocodeine. Side effects are similar to those of other opioids and include itching, nausea and respiratory depression.
References
- ↑ 1.0 1.1 "Nicodicodine [INN:BAN:DCF | SIELC"]. 16 May 2018. http://www.sielc.com/nicodicodine-innbandcf.html.
- ↑ "Drugs Misuse Regulation 1987". Office of the Queensland Parliamentary Counsel. https://www.legislation.qld.gov.au/view/pdf/1996-11-08/sl-1987-dmr.
- ↑ "Misuse of Drugs Act 1971". http://www.legislation.gov.uk/ukpga/1971/38/schedule/2.
- ↑ "The International Drug Control Conventions". United Nations. http://undocs.org/ST/CND/1/Add.1/Rev.4.
- ↑ "Anlage II BtMG - Einzelnorm". https://www.gesetze-im-internet.de/btmg_1981/anlage_ii.html.
- ↑ "Chemistry Dashboard". U.S. Environmental Protection Agency. https://comptox.epa.gov/dashboard/DTXSID40230642.
- ↑ 7.0 7.1 (in en) Painkillers: History, Science, and Issues. ABC-CLIO. 2016. p. 110. ISBN 978-1-4408-3532-2. https://books.google.com/books?id=plWaCwAAQBAJ&q=Nicodicodeine&pg=PA110. Retrieved 12 January 2019.
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