Chemistry:Fadrozole

Fadrozole
Clinical data
Trade names	Afema
Routes of; administration	By mouth
Drug class	Aromatase inhibitor; Antiestrogen
ATC code	None;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile;
CAS Number	102676-47-1 ; hydrochloride: 102676-31-3 ;
PubChem CID	59693;
ChemSpider	53850 ;
UNII	H3988M64PU; hydrochloride: H0Q44H4ECQ ;
KEGG	D02451 ;
ChEMBL	ChEMBL9298 ;
Chemical and physical data
Formula	C14H13N3
Molar mass	223.279 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C#N;
	InChI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2 ; Key:CLPFFLWZZBQMAO-UHFFFAOYSA-N ;
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Short description: Chemical compound

Fadrozole (INN), sold under the brand name Afema (by Novartis), is a selective, nonsteroidal aromatase inhibitor which is or has been used in Japan for the treatment of breast cancer.^[1]^[2]

References

↑ "Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease". J. Med. Chem. 34 (2): 725–36. February 1991. doi:10.1021/jm00106a038. PMID 1825337.
↑ "A study of fadrozole, a new aromatase inhibitor, in postmenopausal women with advanced metastatic breast cancer". J. Clin. Oncol. 10 (1): 111–6. January 1992. doi:10.1200/jco.1992.10.1.111. PMID 1530798. http://www.jco.org/cgi/pmidlookup?view=long&pmid=1530798.

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Clinical data

Trade names	Afema
Routes of administration	By mouth
Drug class	Aromatase inhibitor; Antiestrogen
ATC code	None
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
CAS Number	102676-47-1^Y hydrochloride: 102676-31-3^Y
PubChem CID	59693
ChemSpider	53850^N
UNII	H3988M64PU hydrochloride: H0Q44H4ECQ^Y
KEGG	D02451^Y
ChEMBL	ChEMBL9298^N
Chemical and physical data
Formula	C₁₄H₁₃N₃
Molar mass	223.279 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C#N
InChI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2^N Key:CLPFFLWZZBQMAO-UHFFFAOYSA-N^N
^NY (what is this?) (verify)