Chemistry:Dienestrol diacetate
From HandWiki
Short description: Chemical compound
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| Clinical data | |
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| Trade names | Faragynol, Gynocyrol |
| Other names | Dienestrol acetate; Lipamone |
| Drug class | Nonsteroidal estrogen; Estrogen ester |
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| Chemical and physical data | |
| Formula | C22H22O4 |
| Molar mass | 350.414 g·mol−1 |
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Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol.[1] It is an ester of dienestrol.[1]
| Estrogen | Type | Class | ETD (2–3 weeks) |
EPD (2–3 weeks) |
MSD (2–3 weeks) |
MSD (daily) |
OID (daily) |
TSD (daily) |
|---|---|---|---|---|---|---|---|---|
| Estradiol (non-micronized) | Bioidentical | Steroidal | 30 mg | ≥120–300 mg | 120 mg | 6 mg | ? | ? |
| Estradiol (micronized) | Bioidentical | Steroidal | 6–12 mg | 60–80 mg | 14–42 mg | 1–2 mg | ? | >8 mg |
| Estradiol valerate | Bioidentical | Steroidal | 6–12 mg | 60–80 mg | 14–42 mg | 1–2 mg | ? | >8 mg |
| Estradiol benzoate | Bioidentical | Steroidal | ? | 60–140 mg | ? | ? | ? | ? |
| Estriol | Bioidentical | Steroidal | 20 mga | 120–150 mgb | 28–126 mg | 1–6 mg | ? | ? |
| Estriol succinate | Bioidentical | Steroidal | ? | 140–150 mgb | 28–126 mg | 2–6 mg | ? | ? |
| Estrone sulfate | Bioidentical | Steroidal | 12 mg | 60 mg | 42 mg | 2 mg | ? | ? |
| Conjugated estrogens | Natural | Steroidal | 5–12 mg | 60–80 mg | 8.4–25 mg | 0.625–1.25 mg | ? | 7.5 mg |
| Ethinylestradiol | Synthetic | Steroidal | 200 μg | 1–2 mg | 280 μg | 20–40 μg | 100 μg | 100 μg |
| Mestranol | Synthetic | Steroidal | 300 μg | 1.5–3.0 mg | 300–600 μg | 25–30 μg | ? | ? |
| Quinestrol | Synthetic | Steroidal | 300 μg | 2–4 mg | 500 μg | 25–50 μg | ? | ? |
| Methylestradiol | Synthetic | Steroidal | ? | 2 mg | ? | ? | ? | ? |
| Diethylstilbestrol | Synthetic | Nonsteroidal | 2.5 mg | 20–30 mg | 11 mg | 0.5–2.0 mg | ? | 3 mg |
| Diethylstilbestrol dipropionate | Synthetic | Nonsteroidal | ? | 15–30 mg | ? | ? | ? | ? |
| Dienestrol | Synthetic | Nonsteroidal | 5 mg | 30–40 mg | 42 mg | 0.5–4.0 mg | ? | ? |
| Dienestrol diacetate | Synthetic | Nonsteroidal | 3–5 mg | 30–60 mg | ? | ? | ? | ? |
| Hexestrol | Synthetic | Nonsteroidal | ? | 70–110 mg | ? | ? | ? | ? |
| Hexestrol diacetate | Synthetic | Nonsteroidal | ? | 45 mg | ? | ? | ? | ? |
| Chlorotrianisene | Synthetic | Nonsteroidal | ? | >100 mg | ? | ? | ? | ? |
| Methallenestril | Synthetic | Nonsteroidal | ? | 400 mg | ? | ? | ? | ? |
| Footnotes: a = Very variable, often higher. b = In divided doses, 3x/day; irregular and atypical proliferation. Sources: See template. | ||||||||
| Estrogen | Form | Major brand name(s) | EPD (14 days) | Duration | |
|---|---|---|---|---|---|
| Diethylstilbestrol (DES) | Oil solution | ? | 20 mg | 3 mg ≈ 3 days | |
| Diethylstilbestrol dipropionate | Oil solution | Cyren B | 12.5–15 mg | 2.5 mg ≈ 5 days | |
| Aqueous suspension | ? | 5 mg | ? mg = 21–28 days | ||
| Dimestrol (DES dimethyl ether) | Oil solution | Depot-Cyren, Depot-Oestromon, Retalon Retard | 20–40 mg | ? | |
| Fosfestrol (DES diphosphate)a | Aqueous solution | Honvan | ? | <1 day | |
| Dienestrol diacetate | Aqueous suspension | Farmacyrol-Kristallsuspension | 50 mg | ? | |
| Hexestrol dipropionate | Oil solution | Hormoestrol, Retalon Oleosum | 25 mg | ? | |
| Hexestrol diphosphatea | Aqueous solution | Cytostesin, Pharmestrin, Retalon Aquosum | ? | Very short | |
| Note: All by intramuscular injection unless otherwise noted. Footnotes: a = By intravenous injection. Sources: See template. | |||||
See also
- List of estrogen esters § Esters of other nonsteroidal estrogens
- List of sex-hormonal aqueous suspensions
References
- ↑ 1.0 1.1 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. p. 390. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=RA1-PA129.
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