Chemistry:Mestilbol
From HandWiki
Short description: Chemical compound
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| Trade names | Monomestro, Monomestrol |
| Other names | Monomethylstilbestrol; Diethylstilbestrol monomethyl ether |
| Drug class | Nonsteroidal estrogen; Estrogen ether |
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| Formula | C19H22O2 |
| Molar mass | 282.383 g·mol−1 |
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Mestilbol (brand name Monomestro or Monomestrol), also known as diethylstilbestrol monomethyl ether, is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol.[1][2][3] It was developed by Wallace & Tiernan Company,[3] patented in 1940,[4] and introduced for medical use in the 1940s,[5] but is now no longer marketed. Mestilbol was available both as oral tablets and in oil for intramuscular injection.[3][6] The drug is gradually demethylated in the body into diethylstilbestrol and hence is a prodrug of diethylstilbestrol.[7] Mestilbol is a highly active estrogen,[6] although somewhat less so than diethylstilbestrol,[8] but is longer-lasting in comparison.[9]
See also
References
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. p. 396. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA396.
- ↑ Organic-chemical drugs and their synonyms: (an international survey). VCH Publishers. 1987. p. 923. ISBN 978-0-89573-552-2. https://books.google.com/books?id=k6fwAAAAMAAJ&q=%22monomestro%22.
- ↑ 3.0 3.1 3.2 Council on Drugs (American Medical Association) (1955). New and Nonofficial Drugs. Lippincott. pp. 419–420. https://books.google.com/books?id=0n4YAQAAIAAJ&q=%22Monomestrol%22.
- ↑ Emmet RE, "Monoalkyl ethers of diethylstilboestrol", US patent 2385468, issued 25 September 1945, assigned to US Filter Wallace and Tiernan Inc
- ↑ "Therapy of the Patient in the Menopause: Endocrine Methods". The Journal of Clinical Endocrinology & Metabolism 4 (12): 597–604. 1944. doi:10.1210/jcem-4-12-597. ISSN 0021-972X.
- ↑ 6.0 6.1 Postgraduate Medicine. McGraw-Hill. 1949. p. 347. https://books.google.com/books?id=Cq7yAAAAMAAJ.
- ↑ Annales de Bourgogne. Centre d'études bourguignonnes. 1940. https://books.google.com/books?id=JYlNAAAAMAAJ.
- ↑ A Textbook of Medicine. Saunders. 1951. https://books.google.com/books?id=QUtBAAAAYAAJ.
- ↑ A Textbook of Pharmacology: Principles and Application of Pharmacology to the Practice of Medicine. Saunders. 1952. https://books.google.com/books?id=rFzZT45hG6kC.
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