Chemistry:Triphenylbromoethylene
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Short description: Chemical compound
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| Trade names | Bromylene, Eitriphin, Oestronyl, Prostilban, Tribenorm |
| Other names | TPBE; Tribromophenylethylene; Bromotriphenylethylene; Phenylstilbene bromide; Fenbrostilbenum |
| Drug class | Nonsteroidal estrogen |
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| Formula | C20H15Br |
| Molar mass | 335.244 g·mol−1 |
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Triphenylbromoethylene (TPBE; brand names Bromylene, Eitriphin, Oestronyl, Prostilban, Tribenorm), also known as bromotriphenylethylene or as phenylstilbene bromide, is a synthetic nonsteroidal estrogen of the triphenylethylene group that was marketed in the 1940s similarly to the closely related estrogen triphenylchloroethylene.[1][2]
A diethoxylated derivative of triphenylbromoethylene, estrobin (DBE), is also an estrogen, but, in contrast, was never marketed.[3] An ethylated derivative of triphenylbromoethylene, broparestrol (BDPE), is a selective estrogen receptor modulator (SERM) that has been marketed.[4][5]
See also
References
- ↑ Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. 2001. p. 1861. ISBN 978-3-527-30247-5. https://books.google.com/books?id=zmpqAAAAMAAJ. "C20H15Br. 1607-57-4. Bromotriphenylethene = Triphenylbromoethylene = Phenylstilbene bromide = 1,1',1"-(1-Bromo-1-ethenyl-2-yli- dene)tris[benzene] (•) S Bromylene, Fenbrostilbenum, Oestronyl, Phenylstilbene bromide, Prostilban, Tribenorm U Synthetic estrogen"
- ↑ "Metabolism of the oestrogen triphenylbromoethylene". Nature 163 (4151): 801–802. May 1949. doi:10.1038/163801a0. PMID 18128458. Bibcode: 1949Natur.163..801P.
- ↑ Hormone Assay. Elsevier Science. 22 October 2013. pp. 394–. ISBN 978-1-4832-7286-3. https://books.google.com/books?id=cCzgBAAAQBAJ&pg=PA394.
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 183–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA183.
- ↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 139–. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA139.
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