Chemistry:Hitachimycin
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Short description: Chemical compound
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| Formula | C29H35NO5 |
| Molar mass | 477.601 g·mol−1 |
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Hitachimycin, also known as stubomycin, is a cyclic polypeptide produced by Streptomyces that acts as an antibiotic. It exhibits cytotoxic activity against mammalian cells, Gram-positive bacteria, yeast, and fungi, as well as hemolytic activity; this is mediated by changes at the cell membrane and subsequent lysis.[1] Owing to its cytotoxic activity against mammalian cells and tumors, it was first proposed as an antitumor antibiotic.[2]
As of 2007, it has not been used in a clinical setting.[citation needed]
References
- ↑ "Studies on the biological activity of stubomycin". J. Antibiot. 36 (3): 301–11. 1983. doi:10.7164/antibiotics.36.301. PMID 6833150.
- ↑ "A new antitumor antibiotic, stubomycin". J. Antibiot. 34 (3): 259–65. 1981. doi:10.7164/antibiotics.34.259. PMID 7275806.
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