Chemistry:Miricorilant

From HandWiki

Miricorilant (CORT-118335) is a small molecule that works as a selective glucocorticoid receptor modulator and mineralcorticoid receptor antagonist.[1][2][3][4] It was developed by Corcept Therapeutics for nonalcoholic steatohepatitis[5] and weight gain associated with atypical antipsychotics.[6]

See also

References

  1. ↑ Hunt, Hazel J.; Ray, Nicholas C.; Hynd, George; Sutton, Jon; Sajad, Mohammed; o'Connor, Elizabeth; Ahmed, Shahadat; Lockey, Peter et al. (2012). "Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat". Bioorganic & Medicinal Chemistry Letters 22 (24): 7376–7380. doi:10.1016/j.bmcl.2012.10.074. PMID 23131342. 
  2. ↑ Mammi, C.; Marzolla, V.; Armani, A.; Feraco, A.; Antelmi, A.; Maslak, E.; Chlopicki, S.; Cinti, F. et al. (June 2016). "A novel combined glucocorticoid-mineralocorticoid receptor selective modulator markedly prevents weight gain and fat mass expansion in mice fed a high-fat diet" (in en). International Journal of Obesity 40 (6): 964–972. doi:10.1038/ijo.2016.13. ISSN 1476-5497. PMID 26830012. 
  3. ↑ Nguyen, Elizabeth T.; Berman, Sarah; Streicher, Joshua; Estrada, Christina M.; Caldwell, Jody L.; Ghisays, Valentina; Ulrich-Lai, Yvonne; Solomon, Matia B. (1 August 2019). "Effects of combined glucocorticoid/mineralocorticoid receptor modulation (CORT118335) on energy balance, adiposity, and lipid metabolism in male rats". American Journal of Physiology. Endocrinology and Metabolism 317 (2): E337–E349. doi:10.1152/ajpendo.00018.2019. PMID 31112405. 
  4. ↑ Nguyen, Elizabeth T.; Caldwell, Jody L.; Streicher, Joshua; Ghisays, Valentina; Balmer, Nikolaus J.; Estrada, Christina M.; Solomon, Matia B. (January 2018). "Differential effects of imipramine and CORT118335 (Glucocorticoid receptor modulator/mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats". Behavioural Brain Research 336: 99–110. doi:10.1016/j.bbr.2017.08.045. PMID 28866130. 
  5. ↑ Koorneef, Lisa L; van den Heuvel, José K; Kroon, Jan; Boon, Mariëtte R; ’t Hoen, Peter A C; Hettne, Kristina M; van de Velde, Nienke M; Kolenbrander, Kelsey B et al. (12 October 2018). "Selective glucocorticoid receptor modulation prevents and reverses non-alcoholic fatty liver disease in male mice". Endocrinology 159 (12): 3925–3936. doi:10.1210/en.2018-00671. PMID 30321321. 
  6. ↑ Hunt, Hazel J.; Donaldson, Kirsteen; Strem, Mark; Tudor, Iulia Cristina; Sweet-Smith, Suzanne; Sidhu, Sharan (November–December 2021). "Effect of Miricorilant, a Selective Glucocorticoid Receptor Modulator, on Olanzapine-Associated Weight Gain in Healthy Subjects: A Proof-of-Concept Study". Journal of Clinical Psychopharmacology 41 (6): 632–637. doi:10.1097/JCP.0000000000001470. ISSN 1533-712X. PMID 34369902. 



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