Chemistry:Niperotidine
From HandWiki
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| Preferred IUPAC name
(Z)-N1-[(2H-1,3-Benzodioxol-5-yl)methyl]-N′1-{2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}-2-nitroethene-1,1-diamine | |
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3D model (JSmol)
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| ChEMBL | |
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| KEGG | |
| MeSH | C073716 |
PubChem CID
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| Properties | |
| C20H26N4O5S | |
| Molar mass | 434.51 g·mol−1 |
| Pharmacology | |
| 1=ATC code }} | A02BA05 (WHO) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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Tracking categories (test):
Niperotidine is a histamine antagonist selective for the H2 subtype. It was studied as a treatment for excessive gastric acidity,[1] but withdrawn after human trials showed liver damage.[2]
References
- ↑ Palasciano, G; Maggi, V; Portincasa, P (1990). "The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring". The Italian Journal of Gastroenterology 22 (5): 291–4. PMID 1983712.
- ↑ Gasbarrini, G; Gentiloni, N; Febbraro, S; Gasbarrini, A; Di Campli, C; Cesana, M; Miglio, F; Miglioli, M et al. (1997). "Acute liver injury related to the use of niperotidine". Journal of Hepatology 27 (3): 583–6. doi:10.1016/s0168-8278(97)80365-0. PMID 9314138.
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