Chemistry:Tepirindole
From HandWiki
Tepirindole (INN; developmental code names RU-27592, HR-592) is a tryptamine-related atypical antipsychotic and major tranquilizer which was never marketed.[1][2][3][4][5] It is similar in structure to tryptamines but is not technically a tryptamine itself and is instead a dihydropyridinylindole.[1][6] The drug is said to act on dopamine D2, serotonin 5-HT2, and α1-adrenergic receptors.[3][4] It is a potent dopamine receptor antagonist but reportedly has little propensity to cause catalepsy and has been said to potentially be useful in treating the negative symptoms of schizophrenia.[4][5] The drug may also act as a potent serotonin receptor agonist.[6] Tepirindole was first described in the literature by 1979.[1][6]
See also
References
- ↑ 1.0 1.1 1.2 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. 2014. p. 1159. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA1159. Retrieved 8 October 2024.
- ↑ Drugs: Synonyms and Properties. Wiley. 2002. p. 676. ISBN 978-0-566-08491-1. https://books.google.com/books?id=QxcoEAAAQBAJ&pg=PA676. Retrieved 8 October 2024.
- ↑ 3.0 3.1 "Atypical neuroleptics: role of multiple receptors, endogenous dopamine, and receptor linkage". Acta Psychiatrica Scandinavica. Supplementum 358: 14–20. 1990. doi:10.1111/j.1600-0447.1990.tb05280.x. PMID 1978482.
- ↑ 4.0 4.1 4.2 "Chapter 1 Antipsychotic Agents". Annual Reports in Medicinal Chemistry. 22. Elsevier. 1987. p. 1–10. doi:10.1016/s0065-7743(08)61149-5. ISBN 978-0-12-040522-0. "Several potent blockers of DA receptors are also putative atypical antipsychotics. Tepirindole (HR-592, 25) has a high affinity for DA, 5-HT and NE receptors but has little propensity to cause catalepsy (78)."
- ↑ 5.0 5.1 "Behavioral effects of HR-592, a new derivative of indole". Japanese Journal of Pharmacology 52 (4): 609–619. April 1990. doi:10.1254/jjp.52.609. PMID 2342229.
- ↑ 6.0 6.1 6.2 "Biochemical assessment of the central 5-HT agonist activity of RU 24969 (a piperidinyl indole)". European Journal of Pharmacology 63 (1): 65–72. April 1980. doi:10.1016/0014-2999(80)90117-x. PMID 6155275.
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