Chemistry:Ciclindole

From HandWiki

Ciclindole (INN; developmental code name WIN-27,147-2), also known as cyclindole (USAN), is an antipsychotic of the tetrahydrocarbazolamine family with a tricyclic cyclized tryptamine structure that was never marketed.[1][2]

It displaces spiperone binding in vitro and elevates dopamine levels in the striatum, indicating that it acts as a dopamine D2 receptor antagonist.[2] It also shows apparent affinity for the α1-adrenergic receptor, the serotonin S1 receptor, and the serotonin S2 receptor.[2] However, its affinities for all of the preceding targets are weak, in the low micromolar range.[2]

The related drug flucindole is about 5 to 10 times more potent than ciclindole both in vitro and in vivo.[2]

See also

References

  1. ↑ Triggle, David J. (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. https://books.google.com/books?id=DeX7jgInYFMC&q=cyclindole&pg=PA540. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 "Ciclindole and flucindole: novel tetrahydrocarbazolamine neuroleptics". Progress in Neuro-Psychopharmacology & Biological Psychiatry 8 (4–6): 773–7. 1984. doi:10.1016/0278-5846(84)90057-5. PMID 6152347. 




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