Chemistry:Tiazofurin

Short description: Chemical compound

Tiazofurin

Clinical data
Other names	2-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide
ATC code	L01XX18 (WHO)
Identifiers
IUPAC name (1R)-1-[4-(aminocarbonyl)-1,3-thiazol-2-yl]-1,4-anhydro-D-ribitol
CAS Number	60084-10-8 N
PubChem CID	457954
ChemSpider	403014 Y
UNII	ULJ82834RE
ChEMBL	ChEMBL108358 Y
Chemical and physical data
Formula	C9H12N2O5S
Molar mass	260.26 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(c1nc(sc1)[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)CO)N
InChI InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1 Y Key:FVRDYQYEVDDKCR-DBRKOABJSA-N Y
NY (what is this?)  (verify)

Tiazofurin is a drug which acts as an inhibitor of the enzyme IMP dehydrogenase. Tiazofurin and its analogues were under investigation for potential use in the treatment of cancer, though side effects such as pleuropericarditis and a flu-like syndrome precluded further development. They also show antiviral effects and may be reevaluated as potential options in the treatment of newly emerging viral diseases.