Chemistry:Carboplatin

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Short description: Medication used to treat cancer
Carboplatin
Carboplatin-skeletal.svg
Carboplatin-from-xtal-view-1-Mercury-3D-balls.png
Clinical data
Pronunciation/ˈkɑːrboʊˌplætən/
Trade namesParaplatin, others
AHFS/Drugs.comMonograph
MedlinePlusa695017
Routes of
administration		Intravenous
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailabilitycomplete
Protein bindingVery low
Elimination half-life1.1-2 hours
ExcretionKidney
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC6H12N2O4Pt
Molar mass371.256 g·mol−1
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Carboplatin, sold under the brand name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer.[1] This includes ovarian cancer, lung cancer, head and neck cancer, brain cancer, and neuroblastoma.[1] It is used by injection into a vein.[1]

Side effects generally occur.[1] Common side effects include low blood cell levels, nausea, and electrolyte problems.[2][1] Other serious side effects include allergic reactions and mutagenesis. It may be carcinogenic, but further research is needed to confirm this.[1] Use during pregnancy may result in harm to the baby.[1] Carboplatin is in the platinum-based antineoplastic family of medications and works by interfering with duplication of DNA.[1][3]

Carboplatin was developed as a less toxic analogue of cisplatin.[4] It was patented in 1972 and approved for medical use in 1989.[5] It is on the 2023 World Health Organization's List of Essential Medicines.[6]

Medical uses

Carboplatin is used to treat a number of forms of cancer. This includes ovarian cancer, lung cancer, head and neck cancer, brain cancer, and neuroblastoma. It may be used for some types of testicular cancer but cisplatin is generally more effective.[1] It has also been used to treat triple-negative breast cancer.

Side effects

Relative to cisplatin, the greatest benefit of carboplatin is its reduced side effects, particularly the elimination of nephrotoxic effects. Nausea and vomiting are less severe and more easily controlled.[7]

The main drawback of carboplatin is its myelosuppressive effect. This causes the blood cell and platelet output of bone marrow in the body to decrease quite dramatically, sometimes as low as 10% of its usual production levels. The nadir of this myelosuppression usually occurs 21–28 days after the first treatment, after which the blood cell and platelet levels in the blood begin to stabilize, often coming close to its pre-carboplatin levels. This decrease in white blood cells (neutropenia) can cause complications, and is sometimes treated with drugs like filgrastim. The most notable complication of neutropenia is increased probability of infection by opportunistic organisms, which necessitates hospital readmission and treatment with antibiotics.

Mechanism of action

Carboplatin differs from cisplatin in that it has a bidentate dicarboxylate (the ligand is cyclobutane dicarboxylate, CBDCA) in place of the two chloride ligands. Both drugs are alkylating agents. CBDCA and chloride are the leaving groups in these respective drugs Carboplatin exhibits slower aquation (replacement of CBDCA by water) and thus slower DNA binding kinetics, although it forms the same reaction products in vitro at equivalent doses with cisplatin. Unlike cisplatin, carboplatin may be susceptible to alternative mechanisms. Some results show that cisplatin and carboplatin cause different morphological changes in MCF-7 cell lines while exerting their cytotoxic behaviour.[8] The diminished reactivity limits protein-carboplatin complexes, which are excreted. The lower excretion rate of carboplatin means that more is retained in the body, and hence its effects are longer lasting (a retention half-life of 30 hours for carboplatin, compared to 1.5-3.6 hours in the case of cisplatin).

Like cisplatin, carboplatin binds to and cross-links DNA, interfering with the replication and suppressing growth of the cancer cell.[9][10]

Dose

Calvert's formula is used to calculate the dose of carboplatin. It considers the creatinine clearance and the desired area under curve.[11] After 24 hours, close to 70% of carboplatin is excreted in the urine unchanged. This means that the dose of carboplatin must be adjusted for any impairment in kidney function.[12]

Calvert formula: [math]\displaystyle{ \mathrm{Dose}(\mathrm{mg})= \mathrm{AUC} \cdot (\mathrm{GFR} + 25) }[/math]

The typical area under the curve (AUC) for carboplatin ranges from 3-7 (mg/ml)*min.[12]

Synthesis

Cisplatin reacts with silver nitrate and then cyclobutan-1,1-dicarboxylic acid to form carboplatin.[13]

Carboplatin synthesis.png

History

Carboplatin, a cisplatin analogue, was developed by Bristol Myers Squibb and the Institute of Cancer Research in order to reduce the toxicity of cis platin.[4][14] It gained U.S. Food and Drug Administration (FDA) approval for carboplatin, under the brand name Paraplatin, in March 1989. Starting in October 2004, generic versions of the drug became available.

Research

Carboplatin has also been used for adjuvant therapy of stage 1 seminomatous testicular cancer. Research has indicated that it is not less effective than adjuvant radiotherapy for this treatment, while having fewer side effects.[15] This has led to carboplatin based adjuvant therapy being generally preferred over adjuvant radiotherapy in clinical practice.[16]

Carboplatin combined with hexadecyl chain and polyethylene glycol appears to have increased liposolubility and PEGylation. This is useful in chemotherapy, specifically non-small cell lung cancer.[17]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 "Carboplatin". The American Society of Health-System Pharmacists. https://www.drugs.com/monograph/carboplatin.html. 
  2. ↑ "The side effects of platinum-based chemotherapy drugs: a review for chemists". Dalton Transactions 47 (19): 6645–6653. May 2018. doi:10.1039/c8dt00838h. PMID 29632935. 
  3. ↑ "The state-of-play and future of platinum drugs". Endocrine-Related Cancer 22 (4): R219–R233. August 2015. doi:10.1530/ERC-15-0237. PMID 26113607. 
  4. ↑ 4.0 4.1 "Clinical development of platinum complexes in cancer therapy: an historical perspective and an update". Eur J Cancer 34 (10): 1522–34. 1998. doi:10.1016/s0959-8049(98)00224-x. PMID 9893623. https://www.ejcancer.com/action/showPdf?pii=S0959-8049%2898%2900224-X. 
  5. ↑ (in en) Analogue-based Drug Discovery. John Wiley & Sons. 2006. p. 513. ISBN 9783527607495. https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA513. 
  6. ↑ The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. 2023. WHO/MHP/HPS/EML/2023.02. 
  7. ↑ "10 - Preparative Regimens Used in Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T-Cell Therapies". Manual of Hematopoietic Cell Transplantation and Cellular Therapies. Elsevier. 2023. pp. 125–143. doi:10.1016/B978-0-323-79833-4.00010-3. ISBN 9780323798334. 
  8. ↑ "Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum(II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited". Biochemical Pharmacology 58 (10): 1625–1629. November 1999. doi:10.1016/S0006-2952(99)00250-6. PMID 10535754. 
  9. ↑ "Formation and repair of interstrand cross-links in DNA". Chemical Reviews 106 (2): 277–301. February 2006. doi:10.1021/cr040478b. PMID 16464006. 
  10. ↑ "TUMORS, MALIGNANT / Chemotherapeutic Agents". Encyclopedia of Respiratory Medicine. Academic Press. 2006. pp. 332–338. doi:10.1016/B0-12-370879-6/00409-9. ISBN 9780123708793. 
  11. ↑ "New Guidelines for Carboplatin Dosing". Memorial Sloan Kettering Cancer Center. September 1, 2012. http://www.mskcc.org/cancer-care/clinical-update/new-guidelines-carboplatin-dosing. 
  12. ↑ 12.0 12.1 "Carboplatin dosage: prospective evaluation of a simple formula based on renal function". Journal of Clinical Oncology 7 (11): 1748–1756. November 1989. doi:10.1200/JCO.1989.7.11.1748. PMID 2681557. 
  13. ↑ "30 - Antineoplastics". Synthesis of Essential Drugs. Elsevier. 2006. pp. 389–418. doi:10.1016/B978-044452166-8/50030-3. ISBN 9780444521668. 
  14. ↑ "Discovering early chemotherapy drugs". https://www.icr.ac.uk/about-us/our-achievements/our-scientific-discoveries/we-discovered-chemotherapeutic-agents-which-are-still-in-use-more-than-50-years-later. 
  15. ↑ "Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomised trial". Lancet 366 (9482): 293–300. 2005. doi:10.1016/S0140-6736(05)66984-X. PMID 16039331. 
  16. ↑ "Testicular cancer: Optimal management of stage I seminoma in 2015". Nature Reviews. Urology 12 (5): 249–251. May 2015. doi:10.1038/nrurol.2015.85. PMID 25896179. 
  17. ↑ "Prodrug-based nano-delivery strategy to improve the antitumor ability of carboplatin in vivo and in vitro". Drug Delivery 28 (1): 1272–1280. December 2021. doi:10.1080/10717544.2021.1938754. PMID 34176381. 

Further reading



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